Bucherer反应在精细化工中间体合成中的应用研究  

Application of Bucherer Reaction in the Synthesis of Fine Chemical Intermediates

作　　者：秦威 孔祥文[1] 陶一凡 QIN Wei;KONG Xiang-wen;TAO Yi-fan(Schoolof Science Shenyang University of Chemical Technology,Shenyang 110142,Liaoning China)

机构地区：[1]沈阳化工大学理学院,沈阳110412

出　　处：《染料与染色》2021年第1期31-40,共10页Dyestuffs and Coloration

基　　金：辽宁省普通高等教育本科教学改革研究项目(辽教函[2018]471号)

摘　　要：Bucherer反应作为一个仅需一步便可将萘酚转化为萘胺的有机反应,具有反应条件简单、反应过程易于控制、反应原料便宜易得及反应不产生有害废物等优点,但是它的工业化程度不高。本文叙述了Bucherer反应的机理,重点总结了其在染料、医药、氨基酸及其他有机合成中的应用,并展望了该反应在更多工业化生产中的应用前景。Bucherer reaction,which can convert naphthol to naphthylamine in one step,has the advantages of simple reaction conditions,easy control of reaction process,cheap and easy access to reaction raw materials,and no harmful waste produced in the reaction.But its industrialization is not good.The mechanism of Bucherer reaction was described,and the application of Bucherer reaction in dye,medicine,amino acid and other organic synthesis was summarized.The future application of Bucherer reaction in more industrial production was also prospected.

关 键 词：Bucherer反应 染料 医药 有机合成 

分 类 号：TQ610.1[化学工程—精细化工]