Immunomodulatory nanodiamond aggregate-based platform for the treatment of rheumatoid arthritis  

作　　者：Amanda Pentecost Min Ju Kim Sangmin Jeon Young Ji Ko Ick Chan Kwon Yury Gogotsi Kwangmeyung Kim Kara L.Spiller 

机构地区：[1]Department of Materials Science and Engineering,College of Engineering,Drexel University,Philadelphia,PA,USA [2]School of Biomedical Engineering,Science,and Health Systems,Drexel University,Philadelphia,PA,USA [3]KU-KIST Graduate School of Converging Science and Technology,Korea University,Seoul,South Korea [4]Biomedical Research Institute,Center for Theragnosis,Korea Institute of Science and Technology,Seoul,South Korea

出　　处：《Regenerative Biomaterials》2019年第3期163-174,共12页再生生物材料（英文版）

基　　金：the National Institutes of Health grant R01 HL130037.A.P.was supported by Whitaker International and David L.Boren fellowships.

摘　　要：We previously demonstrated that octadecylamine-functionalized nanodiamond(ND-ODA)and dexamethasone(Dex)-adsorbed ND-ODA(ND-ODA–Dex)promoted anti-inflammatory and proregenerative behavior in human macrophages in vitro.In this study,we performed a pilot study to investigate if these immunomodulatory effects translate when used as a treatment for rheumatoid arthritis in mice.Following local injection in limbs of mice with collagen type II-induced arthritis,microcomputed tomography showed that mice treated with a low dose of ND-ODA and ND-ODA–Dex did not experience bone loss to the levels observed in non-treated arthritic controls.A low dose of ND-ODA and ND-ODA–Dex also reduced macrophage infiltration and expression of proinflammatory mediators iNOS and tumor necrosis factor-a compared to the arthritic control,while a high dose of ND-ODA increased expression of these markers.Overall,these results suggest that ND-ODA may be useful as an inherently immunomodulatory platform,and support the need for an in-depth study,especially with respect to the effects of dose.

关 键 词：drug delivery NANOBIOMATERIALS biomaterial–cell interaction 

分 类 号：TB3[一般工业技术—材料科学与工程]