Impact of the COVID-19 pandemic on liver donation and transplantation:A review of the literature  

作　　者：Riccardo De Carlis Ivan Vella NiccolòIncarbone Leonardo Centonze Vincenzo Buscemi Andrea Lauterio Luciano De Carlis 

机构地区：[1]Department of General Surgery and Transplantation,ASST Grande Ospedale Metropolitano Niguarda,Milan 20162,Italy [2]Department of Surgical Sciences,University of Pavia,Pavia 27100,Italy [3]Department of Medicine and Surgery,University of Milano-Bicocca,Milan 20126,Italy

出　　处：《World Journal of Gastroenterology》2021年第10期928-938,共11页世界胃肠病学杂志（英文版）

摘　　要：The coronavirus disease 2019(COVID-19)pandemic has upended healthcare systems worldwide and led to an inevitable decrease in liver transplantation(LT)activity.During the first pandemic wave,administrators and clinicians were obliged to make the difficult decision of whether to suspend or continue a lifesaving procedure based on the scarce available evidence regarding the risk of transmission and mortality in immunosuppressed patients.Those centers where the activity continued or was heavily restricted were obliged to screen donors and recipients,design COVID-safe clinical pathways,and promote telehealth to prevent nosocomial transmission.Despite the ever-growing literature on COVID-19,the amount of high-quality literature on LT remains limited.This review will provide an updated view of the impact of the pandemic on LT programs worldwide.Donor and recipient screening,strategies for waitlist prioritization,and posttransplant risk of infection and mortality are discussed.Moreover,a particular focus is given to the possibility of donor-to-recipient transmission and immunosuppression management in COVID-positive recipients.

关 键 词：Severe acute respiratory syndrome coronavirus type 2 Liver cirrhosis Donor and recipient screening Donor-to-recipient transmission IMMUNOSUPPRESSION Resource allocation in transplantation 

分 类 号：R657.3[医药卫生—外科学]