颈动脉粥样硬化斑块内新生血管超声造影分级与血脂水平的相关性  

Correlation between ultrasound contrast grading of neovascularization in carotid atherosclerotic plaque and blood lipid level

作　　者：周立平[1] 孙钦亮 王鸿凤 杜启亘[1] ZHOU Liping;SUN Qinliang;WANG Hongfeng;DU Qigen(Department of Ultrasound,the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150000,China)

机构地区：[1]黑龙江中医药大学附属第二医院超声科,哈尔滨市150000 [2]哈尔滨医科大学附属第二医院超声科 [3]哈尔滨市红十字中心医院超声科

出　　处：《临床超声医学杂志》2021年第3期183-186,共4页Journal of Clinical Ultrasound in Medicine

基　　金：黑龙江省自然科学基金项目(A20150153)。

摘　　要：目的探讨冠状动脉粥样硬化性心脏病(CHD)患者颈动脉粥样硬化斑块内新生血管超声造影分级及其与血脂水平的相关性。方法选取颈动脉斑块形成患者146例,其中79例经冠状动脉造影证实为CHD(CHD组,105枚斑块),余67例为非CHD患者(对照组,97枚斑块)。两组均行颈动脉超声、颈动脉超声造影及血脂检查,分析颈动脉斑块内新生血管超声造影分级与血脂水平的相关性。结果CHD组颈动脉斑块超声造影分级以Ⅱ、Ⅲ级为主(73枚),对照组以0、Ⅰ级为主(61枚),两组颈动脉斑块超声造影分级分布情况比较差异有统计学意义(P<0.05)。CHD组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、小而密低密度脂蛋白胆固醇(sdLDL-C)均高于对照组(均P<0.05)。相关性分析显示,CHD组斑块内新生血管超声造影分级与TC、sdLDL-C均呈正相关(r=0.512、0.681,均P<0.05)。结论超声造影可较好地反映CHD患者斑块内新生血管分级,且斑块内新生血管超声造影分级与血脂水平有一定相关性。Objective To evaluate the relationship between the ultrasound contrast grading of neovascularization in carotid atherosclerotic plaques and blood lipid in patients with coronary heart disease(CHD).Methods A total of 146 patients with carotid plaque formation were selected,79 of them were identified as CHD(CHD group,105 plaques)by coronary angiography,and 67 were non CHD patients(control group,97 plaques).All of them were examined by carotid ultrasound,carotid contrast enhanced ultrasound and blood lipid test.The correlation between ultrasound contrast grading of neovascularization in carotid atherosclerotic plaques and blood lipid level was analyzed.Results The grade of carotid plaques were mainly gradeⅡand gradeⅢ(73 plaques)in CHD group,while in control group,those were grade 0 and gradeⅠ(61 plaques).There was significant difference in the distribution of carotid plaques grading between the two groups(P<0.05).Total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),small and dense low density lipoprotein cholesterol(sdLDL-C)of CHD group were higher than those of control group(all P<0.05).Correlation analysis showed that ultrasound contrast grading of neovascularization in carotid atherosclerotic plaques was positively correlated with TC,sdLDL-C in CHD group(r=0.512,0.681,both P<0.05).Conclusion Contrast-enhanced ultrasound can well reflect the angiographic grading of neovascularization in plaques of CHD patients,the angiographic grading of neovascularization in plaques have a certain correlation with blood lipid level.

关 键 词：超声检查 造影剂 冠状动脉粥样硬化性心脏病 颈动脉粥样硬化 新生血管 血脂 

分 类 号：R445.1[医药卫生—影像医学与核医学] R540[医药卫生—诊断学]