血清甘胆酸检测在肝脏疾病诊断中的价值  

Value of serum glycolic acid in the diagnosis of liver diseases

作　　者：刘小梅 甘福生 LIU Xiao-mei;GAN Fu-sheng(Department of Laboratory Medicine,the Second Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Jiangxi Province,Nanchang330012,China)

机构地区：[1]江西中医药大学第二附属医院检验科,江西南昌330012

出　　处：《中国当代医药》2021年第8期171-174,共4页China Modern Medicine

摘　　要：目的探讨血清甘胆酸(CG)检测在肝脏疾病诊断中的价值。方法选取2018年1月~2019年12月江西中医药大学第二附属医院收治的肝脏疾病患者200例作为观察组,再按照肝脏疾病分为肝癌组、病毒性肝炎组和肝硬化组,选取同期接受健康体检的200例健康体检者作为对照组,检测血清CG与其他肝功能指标,比较肝功能指标,分析不同肝脏疾病患者血清CG水平与其他肝功能指标之间的相关性,及肝功能指标对各种肝脏疾病的诊断效能。结果肝癌组的血清CG、总胆汁酸(TBA)、谷草转氨酶(ALT)、谷丙转氨酶(AST)、碱性磷酸酶(ALP)、总胆红素(TBil)水平均高于对照组、病毒性肝炎组和肝硬化组,差异有统计学意义(P<0.05);肝硬化组的各项指标均高于病毒性肝炎组和对照组,差异有统计学意义(P<0.05);病毒性肝炎组的各项指标均高于对照组,差异有统计学意义(P<0.05)。在病毒性肝炎组、肝硬化组、肝癌组中,血清CG与TBA、ALT、AST、ALP、TBil均呈正相关(P<0.05)。血清CG对病毒性肝炎、肝硬化、肝癌的诊断效能均高于其他肝功能指标,差异均有统计学意义(P<0.05)。结论血清CG在肝脏病变中普遍出现异常增高情况,血清CG对肝脏病变具有良好的鉴别诊断价值。Objective To explore the value of serum glycocholic acid(CG)in the diagnosis of liver diseases.Methods A total of 200 patients with liver disease admitted to the Second Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2018 to December 2019 were selected as the observation group,further according to liver disease,they were divided into liver cancer group,viral hepatitis group and cirrhosis group,and 200 healthy subjects who received physical examination during the same period were selected as the control group,serum CG and other liver function indexes were detected.Liver function indexes were compared,and the correlation between serum CG level and other liver function indexes in patients with different liver diseases was analyzed,as well as the diagnostic efficacy of liver function indexes for various liver diseases.Results Serum levels of CG,total bile acid(TBA),glutamic-oxalacetic transaminase(ALT),alanine aminotransferase(AST),alkaline phosphatase(ALP)and total bilirubin(TBil)in liver cancer group were higher than those in control group,viral hepatitis group and cirrhosis group,the differences were statistically significant(P<0.05).The indexes of cirrhosis group were higher than those of viral hepatitis group and control group,the differences were statistically significant(P<0.05).The indexes of viral hepatitis group were higher than those of the control group,the differences were statistically significant(P<0.05).In viral hepatitis group,cirrhosis group and liver cancer group,there was a positive correlation between serum CG and TBA,ALT,AST,ALP,TBil(P<0.05).The diagnostic efficacy of serum CG in viral hepatitis,liver cirrhosis and liver cancer was higher than that of other liver function indexes,and the differences were statistically significant(P<0.05).Conclusion Serum CG is usually abnormally elevated in liver lesions.Serum CG has a good value in differential diagnosis of liver lesions.

关 键 词：肝脏疾病 甘胆酸 肝功能 诊断 

分 类 号：R446[医药卫生—诊断学]