高流量氧疗联合沙美特罗替卡松粉吸入剂治疗慢性阻塞性肺疾病并发呼吸衰竭效果观察  

Effect of high flow oxygen therapy combined with salmeterol tecasone powder inhalation in the treatment of chronic obstructive pulmonary disease combined with respiratory failure

作　　者：丁丽丽[1] Ding Lili(Xinxiang First People's Hospital,Henan 453000)

机构地区：[1]新乡市第一人民医院,河南453000

出　　处：《天津药学》2021年第1期45-47,共3页Tianjin Pharmacy

摘　　要：目的:探讨高流量氧疗对慢性阻塞性肺疾病(COPD)并发呼吸衰竭患者血气指标和舒适度的影响。方法:选择2019年1-10月本院收治的COPD并发呼吸衰竭患者90例,采用随机数字表法分为两组,各45例。两组均予以沙美特罗替卡松粉吸入剂治疗,1吸/次,2次/d;此外对照组采用低流量氧疗:控制氧流量在3 L内,浓度为25%~30%,每天时间为16 h以上,需对患者生命体征、血气分析进行密切观察,根据病情变化酌情调整治疗方案;观察组行高流量氧疗:采用新西兰Fisher-Paykel公司Optiflow经鼻氧疗系统,流量20~40 L/min,浓度30%~50%,37℃、100%相对湿度气体。比较两组血气指标和舒适度。结果:两组治疗前血气指标比较,差异无统计学意义(P>0.05);两组治疗后PaCO2降低,SaO2、pH和PaO2水平均升高,且观察组变化幅度更大(P<0.05)。观察组舒适度评分为(4.26±0.34)分,高于对照组的(3.19±1.02)分,差异有统计学意义(P<0.05)。结论:与低流量氧疗相比,COPD并发呼吸衰竭患者使用高流量氧疗联合沙美特罗替卡松粉吸入剂效果更佳,患者血气指标改善更明显,舒适度更高,值得推广应用。Objective:To investigate the effect of high flow oxygen therapy on blood gas indexes and comfort levels in patients with chronic obstructive pulmonary disease(COPD)complicated with respiratory failure.Methods:A total of 90 COPD patients with respiratory failure admitted to our hospital from January to October 2019 were selected and divided into two groups by random number table method,with 45 cases in each group.Both groups were treated with salmeterol ticasone powder inhalation,1 suction/time,twice per day.In addition,low-flow oxygen therapy was used in the control group:oxygen flow was controlled within 3 L,the concentration was 25%~30%,and the time was more than 16 hours per day.Vital signs and blood gas analysis of the patients were closely observed,and the treatment plans were adjusted according to the changes of the condition.The observation group was treated with high-flow oxygen therapy by using Optiflow nasal oxygen therapy system(Fisher-Paykel Co.,New Zealand)with flow rate of 20~40 L/min,concentration 30%~50%,37℃,100%relative humidity gas.Blood gas index and comfort level were compared between the two groups.Results:There was no significant difference in blood gas index between the two groups before treatment(P>0.05).After treatment,the PaCO2 decreased and the levels of SaO2,pH and PaO2 increased in both groups,and the change range of the observation group was greater(P<0.05).The comfort score of the observation group(4.26±0.34)was higher than that of the control group(3.19±1.02),and the difference was statistically significant(P<0.05).Conclusion:Compared with low-flow oxygen therapy,high-flow oxygen therapy combined with inhalation of salmeterol ticasone powder in COPD patients with respiratory failure has better effect,and the improvement of blood gas indexes is more obvious,and the comfort level is higher,which is worthy of promotion and application.

关 键 词：慢性阻塞性肺疾病 呼吸衰竭 高流量氧疗 血气指标 舒适度 

分 类 号：R974[医药卫生—药品]