首发未用药抑郁症患者认知功能障碍与血清BDNF水平相关性研究  

Study on the Correlation between Cognitive Impairment and Serum BDNF Level in Patients with First-episode Drugna?ve Depression Disorder

作　　者：朱明环 黄瑛[1] 朱娜[1] 师典红[1] 刘旻佳[1] 金莹[1] 孙喜蓉[1] ZHU Ming-huan;HUANG Ying;ZHU Na(Mental Health Center of Pudong New District,Shanghai,200124,China)

机构地区：[1]上海市浦东新区精神卫生中心,上海200122

出　　处：《中国初级卫生保健》2021年第3期90-92,共3页Chinese Primary Health Care

基　　金：上海市浦东新区卫计委重点学科(PWZxk2017-29)。

摘　　要：目的:探讨血清脑源性神经营养因子与中国汉族首发未用药抑郁症患者认知功能的关系。方法:对50例FDD组患者和50名健康对照组人员进行血清BDNF水平检测;采用威斯康星卡片分类测试(WCST)对FDD组患者和健康对照组进行认知功能评估。结果:FDD组患者血清BDNF水平显著低于健康对照组。FDD患者WCST的完成分类数(Cc)、错误应答数(Re)、持续性错误数(Rpe)及非持续性错误(nRpe)均显著差于健康对照组。在FDD患者中,血清BDNF水平与WCST完成分类数评分呈正相关,并且与错误应答数(Re)和持续性错误数(Rpe)评分呈负相关。结论:低BDNF可能与抑郁症易感性及其认知功能损害具有相关性。OBJECTIVE To investigate the correlation of serum brain-derived neurotrophic factor and cognitive function of first-episode drug-na?ve depression disorder patients in Chinese Han population.METHODS Serum BDNF levels were measured in 50 pa-tients with FDD and 50 healthy controls.Wisconsin Card Sorting Test(WCST)was used to evaluate the cognitive function of patientswith FDD and healthy controls.RESULTS The level of serum BDNF in patients with FDD was significantly lower than healthy con-trols.The performance of WCST completion classification(Cc),error response number(Re),persistent error number(Rpe)andnon-persistent error(n Rpe)in the FDD group were significantly worse than healthy controls.The level of serum BDNF was positive-ly correlated with the score of WCST completion classification(Cc),and negatively correlated with the score of error response num-ber(Re),persistent error number(Rpe).CONCLUSION Low BDNF could be associated with the susceptibility and cognitive impair-ment of depression disorder.

关 键 词：抑郁症 脑源性神经营养因子 认知功能 

分 类 号：R395[哲学宗教—心理学]