MSCs-肠道菌群相互调控关系在IBD治疗中的作用  

Effects of interaction between mesenchymal stem cells and gut microbiota in treatment of inflammatory bowel disease

作　　者：刘爱茹 杨少鹏 张晓岚[1] Ai-Ru Liu;Shao-Peng Yang;Xiao-Lan Zhang(Department of Gastroenterology,the Second Hospital of Hebei Medical University,Shijiazhuang 050035,Hebei Province,China)

机构地区：[1]河北医科大学第二医院消化内科,河北省石家庄市050035

出　　处：《世界华人消化杂志》2021年第6期312-318,共7页World Chinese Journal of Digestology

摘　　要：炎症性肠病(inflammatory bowel diseases,IBD)是一种慢性复发性非特异性肠道疾病,其病因和发病机制尚未完全阐明.研究证实肠道菌群与肠粘膜之间异常的免疫调控在IBD的发生发展中起着决定性作用,纠正菌群失调的肠道微生态疗法对IBD的治疗有着重要的临床意义.间充质干细胞(mesenchymal stem cells,MSCs)在IBD的应用中显示出积极的治疗前景,其有望成为IBD的新兴治疗手段.MSCs除了免疫抑制、组织修复的作用以外,还有助于恢复正常肠道菌群的多样性及丰度,同时,肠道菌群对MSCs的功能活动同样起着重要的调控作用.因此在IBD的环境背景下,MSCs与肠道微生态疗法的联合应用可能会取得更好的临床治疗效果.本文就IBD肠道菌群特征及菌群靶向治疗现状,肠道菌群与宿主肠粘膜上皮之间以及MSCs与肠道菌群之间的相互调控关系在IBD治疗中的作用做一综述,可为探究MSCs-肠道菌群相互作用提供重要指导意义.Inflammatory bowel disease(IBD)is considered a chronic recurrent non-specific enteropathy whose etiology and pathology have yet been fully elucidated.Abnormal immune regulation between gut microbiota and the intestinal mucosa plays a crucial role in the development of IBD.Accordingly,intestinal microecological therapy to correct the imbalance of gut microbiota has important clinical significance.The application of mesenchymal stem cells(MSCs)in IBD has shown a promising therapeutic prospect based on its ability of immunosuppression and tissue repair,and more importantly,MSCs contribute to restoring the diversity and abundance of gut microbiota.And in the same way,gut microbiota produces indispensable effects in regulating the functional activities of MSCs.Therefore,the combined application of MSCs and intestinal microecological therapy may lead to higher clinical remission rates in the context of IBD.This paper reviews the characteristics of gut microbiota in IBD,the current status of microbe-targeted therapies,the gut microbiota-intestinal mucosal epithelium interaction,and the effects of interaction between MSCs and gut microbiota interaction in the treatment of IBD,with an aim to provide meaningful guidance for the further investigation of MSCs-gut microbiota interaction in this new field.

关 键 词：炎症性肠病 肠道菌群 间充质干细胞 肠黏膜上皮 

分 类 号：R574[医药卫生—消化系统]