重症颅脑损伤患者不同颅内压与视神经鞘直径、血清S100β、NSE的相关性  

Correlation between different intracranial pressure and optic nerve sheath diameter,serum S100β,NSE in patients with severe craniocerebral injury

作　　者：曾坚锋 李钢[1] 刘仲海[1] 江振忠 ZENG Jianfeng;LI Gang;LIU Zhonghai;JIANG Zhenzhong(Department of Neurosurgery,Sanya Central Hospital/Hainan Third People′s Hospital,Sanya,Hainan 572000,China)

机构地区：[1]三亚中心医院/海南省第三人民医院神经外科,海南三亚572000

出　　处：《国际检验医学杂志》2021年第6期704-706,共3页International Journal of Laboratory Medicine

基　　金：海南省医疗卫生科技创新项目(2014YW40)。

摘　　要：目的探究重症颅脑损伤患者的颅内压与视神经鞘直径、血清中枢神经特异性蛋白(S100β)、神经元特异性烯醇化酶(NSE)的相关性。方法回顾性选取该院2017年10月至2019年12月收治的80例重症颅脑损伤患者,根据腰椎穿刺颅内压测量分为升高组(41例)和对照组(39例)。分别测量两组患者视神经鞘直径、血清S100β、NSE水平。采取Spearman分析进行双变量相关分析。结果升高组右眼直径、左眼直径和两眼平均值均明显高于对照组,差异有统计学意义(P<0.05)。升高组血清S100β、NES水平明显高于对照组,差异有统计学意义(P<0.05)。颅内压的升高与视神经鞘直径、血清S100β和NSE呈正相关(r=0.848、0.865、0.866,P<0.05)。结论当重症颅脑损伤患者出现颅内压升高时,视神经鞘直径、血清S100β、NSE水平也会随之升高,与颅内压的升高呈正相关。Objective To investigate the correlation between different intracranial pressure and optic nerve sheath diameter,serum central nerve specific protein(S100β),neuron specific enolase(NSE)in patients with severe craniocerebral injury.Methods A total of 80 patients with severe craniocerebral injury in the hospital from October 2017 to December 2019 were retrospectively enrolled in the study,comprising of elevated group(41 cases)and normal group(39 cases)according to the intracranial pressure measurement via lumbar puncture.The optic nerve sheath diameter,serum S100βand NSE were measured in two groups.The Spearman analysis was used to carry out bivariate correlation analysis.Results The diameter of the right eye,the diameter of the left eye,and the mean of the two eyes in the elevated group were significantly higher than those in the normal group,and the differences were statistically significant(P<0.05).Serum S100βand NES in the elevated group was significantly higher than that in the normal group,and the differences were statistically significant(P<0.05).The increase in intracranial pressure was positively correlated with the optic nerve sheath diameter,serum S100βand NSE(r=0.848,0.865,0.866,P<0.05).Conclusion When the intracranial pressure increases in patients with severe craniocerebral injury,the optic nerve sheath diameter,serum S100β,and NSE will also increase,which are positively correlated with the increase in intracranial pressure.

关 键 词：颅内压重症颅脑损伤 视神经鞘直径 中枢神经特异性蛋白 神经元特异性烯醇化酶 

分 类 号：R446.1[医药卫生—诊断学] R446.8[医药卫生—临床医学]