MicroRNA在非洲猪瘟研究中的应用  

Effects of MicroRNA in African Swine Fever

作　　者：张兆博 张思诗 汉可欣 李晓易 文雪霞 汉丽梅[1,4] ZHANG Zhao-bo;ZHANG Si-shi;HAN Ke-xin;LI Xiao-yi;WEN Xue-xia;HAN Li-mei(College of Animal Science and Veterinary Medicine,Shenyang Agricultural University,Shenyang,Liaoning,110866,China;Shanghai Veterinary Research Institute,CAAS,Shanghai 200241,China;Changchun Normal University,Changchun,Jilin,130031,China;Key Laboratory of Livestock Infectious Diseases in Northeast China,Ministry of Education,Shenyang,Liaoning,110866,China)

机构地区：[1]沈阳农业大学畜牧兽医学院,辽宁沈阳110866 [2]中国农业科学院上海兽医研究所,上海200241 [3]长春师范大学,吉林长春130031 [4]东北畜禽疫病研究教育部重点实验室,辽宁沈阳110866

出　　处：《动物医学进展》2021年第4期120-123,共4页Progress In Veterinary Medicine

基　　金：辽宁省大学生创新创业训练计划项目(201910157302);辽宁省博士科研启动基金项目(2019-BS-204)。

摘　　要：microRNA是非编码RNA中一种重要的不具有编码能力的调节RNA,它广泛存在于真核生物体内并对机体的发育、细胞凋亡、基因表达及蛋白质表达等一系列生物学过程起调控作用。非洲猪瘟(African swine fever,ASF)是一种传染性强、危害大的急性传染病,已严重危害我国养猪业的正常发展。对ASF发病过程中microRNA的研究已成为近年来ASF的研究热点之一。论文对近年来ASF发病过程中的microRNA的作用及其机制进行综述,为未来microRNA在ASF防控中发挥作用提供参考。miRNA is a kind of regulatory RNA without coding potential,it widely exists in the eucaryon and plays a regulatory role in a series of biological processes such as cell development,cell apoptosis,gene expression and protein coding.African swine fever(ASF)is an acute infectious disease with serious harm and high infectivity which had already endangered the development of swine breeding industry in China.The analysis of the miRNAs during the pathogenesis of ASF had become a hotspot in ASF research in recent years.In this paper,we reviewed the function and mechanism of the miRNAs during the pathogenesis of ASF in order to provide the theoretical basis for the prevention strategies and vaccine development of ASF in the future.

关 键 词：非洲猪瘟 MICRORNA 非洲猪瘟病毒 

分 类 号：S852.651[农业科学—基础兽医学]