封闭负压引流技术联合针对性护理对糖尿病足溃疡区血管新生的影响  

Effect of vacuum sealing drainage combined with targeted nursing on angiogenesis in diabetic foot ulcer area

作　　者：娄秀娥[1] 杨焕芝[1] 李静[1] Lou Xiue;Yang Huanzhi;Li Jing(Department of Geriatrics,Binzhou Central Hospital,Binzhou 251700,China)

机构地区：[1]滨州市中心医院老年科,251700

出　　处：《国际医药卫生导报》2021年第6期920-924,共5页International Medicine and Health Guidance News

摘　　要：目的探讨封闭负压引流技术联合针对性护理对糖尿病足溃疡区血管新生的影响。方法选择2017年7月至2019年10月收治的糖尿病足溃疡(DFU)患者116例为研究对象,采用随机数字表法分为两组,各58例。对照组给予常规清创处理,观察组在对照组基础上给予封闭负压引流技术(VSD)联合针对性护理;比较两组患者创面愈合时间、创面愈合率、创面血管新生指标、SAS、SDS评分的差异。结果观察组创面愈合时间为(16.12±2.66)d,明显短于对照组(20.54±2.72)d,创面愈合率为(65.26±10.45)%,明显高于对照组(38.98±11.26)%,差异均有统计学意义(均P<0.05);治疗前,两组患者创面组织中血管新生分子指标表达量比较,差异均无统计学意义(均P>0.05);治疗后3、5、7 d时,观察组创面组织中血管新生分子VEGF、VEGFR、CD105、MMP9蛋白表达量均明显高于治疗前及对照组,差异均有统计学意义(均P<0.05);治疗前,两组患者SAS、SDS评分比较,差异均无统计学意义(均P>0.05);治疗后,观察组SAS、SDS评分分别为(44.68±5.50)分、(42.56±5.52)分,均明显低于对照组(50.21±5.45)分、(52.16±5.47)分,差异均有统计学意义(均P<0.05)。结论VSD可调节糖尿病足溃疡创面VEGF、CD105等血管新生分子因子表达,促进溃疡创面血管新生;联合针对性护理,可缓解患者焦虑抑郁状态,缩短DFU创面愈合时间,提高创面修复率。Objective To investigate the effect of vacuum sealing drainage combined with targeted nursing on angiogenesis in diabetic foot ulcer area.Methods A total of 116 patients with diabetic foot ulcer(DFU)admitted from July 2017 to October 2019 were selected as the research objects and were randomly divided into observation group and control group with 58 cases in each group.The control group was given conventional debridement,and the observation group was given vacuum sealing drainage(VSD)combined with targeted nursing on the basis of the control group.The differences of wound healing time,wound healing rate,wound angiogenesis index,SAS and SDS scores between the two groups were compared.Results The wound healing time of the observation group was significantly shorter than that of the control group[(16.12±2.66)d vs.(20.54±2.72)d],and the wound healing rate was significantly higher than that of the control group[(65.26±10.45)%vs.(38.98±11.26)%](both P<0.05).There were no statistically significant differences in wound angiogenesis indexes between the two groups before treatment(all P>0.05);after 3,5,7 days of treatment,the expressions of VEGF,VEGFR,CD105,MMP9 protein in wound tissue of the observation group were significantly higher than those of the control group and those after treatment(all P<0.05).There were no statistically significant differences in SAS and SDS scores between the two groups(both P>0.05);after treatment,SAS and SDS scores in the observation group were(44.68±5.50)points,(42.56±5.52)points,which were significantly lower than those in the control group[(50.21±5.45)points,(52.16±5.47)points](both P<0.05).Conclusion VSD can regulate the expression of VEGF,CD105,and other angiogenesis molecular factors in diabetic foot ulcer wound,promote angiogenesis of ulcer wound;combined with targeted nursing,it can relieve anxiety and depression of patients,shorten the healing time of DFU wound,and improve the wound repair rate.

关 键 词：创面愈合 糖尿病足 溃疡 负压引流 血管新生 

分 类 号：R473.5[医药卫生—护理学]