PRV与先天免疫  

PRV and Innate Immunity

作　　者：梁旺旺 LIANG Wang-wang(Fujian College of Life Sciences,Fujian Normal University,Fuzhou,Fujian 350000)

机构地区：[1]福建师范大学福建生命科学学院,福建福州350000

出　　处：《农业灾害研究》2020年第7期19-20,共2页Journal of Agricultural Catastrophology

摘　　要：猪伪狂犬病病毒(PRV)是引起猪伪狂犬病的病毒,猪为主要天然宿主,通常受感染的猪会表现出各种临床症状。PRV在吸附、注入、组装以及释放等感染过程中都会触发天然免疫反应机制,可以通过多种途径产生抗病毒的多功能因子,比如干扰素等。而PRV具有极强的免疫逃避能力,能够通过抑制STAT信号通路中IFN的表达、抑制MHCⅠ类分子的抗原递呈作用、抑制NK细胞对感染细胞的裂解作用等方式实现细胞免疫逃避。本文从干扰素、TLRs通路等方面阐述了PRV与先天免疫的关系。Porcine pseudorabies virus(PRV)is a virus that causes porcine pseudorabies.Pigs are the main natural host,and infected pigs usually show various clinical symptoms.PRV triggers the natural immune response mechanism during the infection process such as adsorption,injection,assembly,and release,and can produce multi-functional antiviral factors,such as interferon,through a variety of ways.PRV has a strong immune evasion ability,which can achieve cellular immune evasion by inhibiting the expression of IFN in the STAT signaling pathway,inhibiting the antigen presentation of MHC class I molecules,and inhibiting the lysis of NK cells on infected cells.This article expounds the relationship between PRV and innate immunity from interferon and TLRs pathway.

关 键 词：PRV 先天免疫 干扰素 TLRs通路 ERK途径 cGAS-STING通路 

分 类 号：S852.4[农业科学—基础兽医学]