泌尿生殖道标本解脲脲原体和人型支原体检测及抗菌药物敏感性试验结果分析  

Detection and antimicrobial susceptibility testing of Ureaplasma urealyticum and Mycoplasma hominis isolates from urogenital tract specimens

作　　者：殷怡华[1] 张贤华[2] YIN Yihua;ZHANG Xianhua(Department of Gynecology,Shanghai First Maternity and Infant Hospital,Tongji University School of Medicine,Shanghai 201204,China)

机构地区：[1]同济大学附属上海市第一妇婴保健院妇科,上海201204 [2]同济大学附属上海市第一妇婴保健院检验科,上海201204

出　　处：《中国感染与化疗杂志》2021年第2期201-204,共4页Chinese Journal of Infection and Chemotherapy

摘　　要：目的了解泌尿生殖道标本解脲脲原体和人型支原体对常用抗菌药物敏感性,为临床抗菌药物选择提供客观依据。方法采用商品化的支原体培养及药敏试验试剂盒,对2016—2018年连续3年同济大学附属上海市第一妇婴保健院泌尿生殖道标本进行支原体检测及药敏测定。结果3年间共采集泌尿生殖道标本35006份,12572份(35.9%)标本检出解脲脲原体,1073份(3.1%)标本同时检出解脲脲原体与人型支原体,15份(0.04%)标本仅检出人型支原体。解脲脲原体、人型支原体对四环素、多西环素、克拉霉素和交沙霉素敏感率高(≥93.3%);但解脲脲原体与人型支原体混合体,仅对多西环素、米诺环素、交沙霉素保持有较高敏感率(≥70.4%)。生殖道支原体对喹诺酮类药物敏感率低(≤46.7%)。结论泌尿生殖道支原体以解脲脲原体多见;对喹诺酮类耐药性高,应根据培养及药敏结果选择抗菌药物。Objective To investigate the susceptibility of Ureaplasma urealyticum and Mycoplasma hominis isolates from urogenital tract specimens to commonly used antibiotics for improving clinical use of antibiotics.Methods The urogenital tract specimens were collected from patients suspected of urogenital tract infection in our hospital from 2016 to 2018.Mycoplasma species were identified and tested for their susceptibility with commercial testing kit.Results A total of 35006 urogenital specimens were collected during the three years.Ureaplasma urealyticum was detected in 12572(35.9%)specimens,Ureaplasma urealyticum+Mycoplasma hominis were detected in 1073(3.1%)specimens,and Mycoplasma hominis in 15(0.04%)specimens.Ureaplasma urealyticum and Mycoplasma hominis isolates were highly sensitive to tetracycline,doxycycline,clarithromycin and josamycin(≥93.3%).However,only doxycycline,minocycline,and josamycin showed high inhibition rate(≥70.4%)in specimens with mixed Ureaplasma urealyticum+Mycoplasma hominis.The Ureaplasma urealyticum and Mycoplasma hominis isolates showed low susceptibility rates to quinolones(≤46.7%).Conclusions Ureaplasma urealyticum is the most common Mycoplasma in genitourinary tract.Ureaplasma urealyticum and Mycoplasma hominis are highly resistant to quinolones.Antimicrobial treatment should be prescribed according to the results of culture and antimicrobial susceptibility testing.

关 键 词：泌尿生殖道 解脲脲原体 人型支原体 药物敏感性 

分 类 号：R375[医药卫生—病原生物学]