过敏性紫癜患儿急性期免疫状态分析及临床意义  

Analysis of Acute Immune Status in Children with Allergic Purpura and its Clinical Significance

作　　者：罗文春 LUO Wenchun(Jinzhou Women and Infants Hospital,Jinzhou 121000,China)

机构地区：[1]锦州市妇婴医院,辽宁锦州121000

出　　处：《中国医药指南》2021年第5期82-83,共2页Guide of China Medicine

摘　　要：目的本研究通过对我院过敏性紫癜患者免疫球蛋白、T淋巴细胞亚群进行回顾分析,探讨过敏性紫癜患儿急性期免疫状态分析及临床意义。方法 2018年1月至2018年12月我院接收确诊为过敏性紫癜急性期患儿50例作为观察组,选择同期我院门诊体检的健康儿童50例作为对照组,观察组于入院第2天、对照组于体检当日清晨空腹采集外周静脉血6 m L,各取3 m L外周静脉血放在非抗凝管,采用散射比浊法检测血清免疫球蛋白;剩余3 m L外周静脉血放入抗凝管,采用流式细胞术方法检测血清T淋巴细胞亚群,比较两组患儿的血清免疫球蛋白指标(Ig A、Ig M、Ig G)和血清T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))。结果 (1)观察组血清Ig A、Ig M水平明显比对照组高,Ig G水平明显比对照组低,P<0.05。(2)观察组血清CD8^(+)水平明显高于对照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平明显低于对照组,差异均显著(P<0.05)。结论通过监测过敏性紫癜患儿急性期的血清免疫球蛋白、血清T淋巴细胞亚群,及时掌握患者免疫功能的变化特征,从而判断患者的病情,为急性期过敏性紫癜患者的治疗和预后的改善提供有价值的依据。Objective In this study,immunoglobulin and T lymphocyte subsets of patients with allergic purpura in our hospital were retrospectively analyzed to explore the analysis and clinical significance of the acute immune status of children with allergic purpura.Methods Form January 2018 to December2018,our hospital to receive a diagnosis of allergic purpura in children with 50 cases in the acute phase of as observation group,choose the same hospital outpatient medical health 50 cases as control group,children allergic purpura group in the hospital the next day,the control group on the examination day gathering early in the morning on an empty stomach peripheral venous blood 6 m L,each 3 m L peripheral venous blood in the anticoagulant tube,scattering turbidimetric method is used to detect serum immunoglobulin.The remaining 3 m L peripheral venous blood was put into the anticoagulant tube,and the serum T lymphocyte subsets were detected by flow cytometry.Serum immunoglobulin indexes (Ig A,Ig M,Ig G) and serum T lymphocyte subsets (CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)) of the two groups were compared.Results (1) serum Ig A and Ig M levels in the observation group were significantly higher than those in the control group,and Ig G levels were significantly lower than those in the control group,P<0.05.(2) The serum CD8^(+)level in the observation group was significantly higher than that in the control group,and the CD3^(+),CD4^(+),CD4^(+)/CD8^(+)level was significantly lower than that in the control group(P<0.05).Conclusion The body’s immune function in patients with acute allergic purpura is unusual,can through the monitoring of the patient’s serum immunoglobulin,serum levels of T lymphocyte subsets,timely grasp the characteristics of the immune function of patients with,to determine the patient’s condition,for the treatment of acute allergic purpura patients and provide valuable basis for the improvement in prognosis.

关 键 词：过敏性紫癜 急性期 免疫状态分析 临床意义 

分 类 号：R554.6[医药卫生—血液循环系统疾病]