507例男性生殖道感染病原体分布及耐药特征  

Distribution and antimicrobial resistance of multiple pathogens in 507 males with genital tract infections

作　　者：赵立红[1] 赵书平[1] 聂升刚[1] 孙晶 姜同峰[2] ZHAO Lihong;ZHAO Shuping;NIE Shenggang;SUN Jing;JIANG Tongfeng(Department of Clinical Laboratory,Tai'an City Central Hospital,Taian 271000,Shandong,China;Department of Clinical Dermatovenereology,Tai'an City Central Hospital,Taian 271000,Shandong,China)

机构地区：[1]泰安市中心医院检验科,山东泰安271000 [2]泰安市中心医院皮肤性病科,山东泰安271000

出　　处：《山东大学学报（医学版）》2021年第1期55-58,共4页Journal of Shandong University:Health Sciences

基　　金：山东省医药卫生科技发展计划资助项目(2017WS175)。

摘　　要：目的分析泰安市男性生殖道感染患者病原体的分布特点与耐药特征。方法选取2016年9月至2018年9月泰安市7家医院泌尿外科、生殖科或性病科男性患者,采集标本,进行病原体培养与药敏试验测定。淋病奈瑟菌采用含万古霉素的巧克力平板进行培养,质谱法进行鉴定,琼脂稀释法进行药敏试验;支原体培养采用肉汤培养法,药敏试验采用肉汤稀释法;衣原体检测采用抗原诊断法。结果筛选出507例阳性标本中,单纯解脲脲原体(UU)感染率为39.84%(202/507),单纯淋病奈瑟菌(NG)感染率为23.08%(117/507),多病原体混合感染率为26.43%(134/507)。161株NG对环丙沙星(CIP)、青霉素(PEN)、四环素(TET)的耐药率分别为96.90%、96.27%和96.65%,对头孢曲松(CRO)和头孢克肟(CFM)的低敏率分别为9.32%和9.94%。UU与人型支原体(MH)对美满霉素(MIN)、强力霉素(DOX)和交沙霉素(JOS)敏感率均在90%以上。结论泰安市男性生殖道感染中,主要为单一病原体感染,单纯UU感染居于第1位,其次为单纯NG感染。CRO等第三代头孢菌素仍为泰安市治疗男性淋病的首选药物,MIN、DOX和JOS为泰安市治疗男性生殖道支原体感染的首选药物。Objective To analyze the distribution and antimicrobial resistance of multiple pathogens in males with genital tract infections. Methods Multiple pathogens in clinical specimens collected from 7 hospitals in Tai?an during Sep. 2016 and Sep. 2018 were cultured. Neisseria gonorrhoeae(NG) was cultured on a chocolate tablet containing vancomycin and identified with mass spectrometry, and drug susceptibility was tested with agar dilution method. Ureaplasma urealyticum(UU) was cultured in broth, and drug susceptibility was tested with broth dilution method. Mycoplasma hominis(MH) was tested with IES. Results A total of 507 positive samples were screened out, among which the infection rate of simple UU, simple NG, and multiple pathogens was 39.84%, 23.08%, and 26.43%, respectively. The resistance rate of NG against ciprofloxacin(CIP), penicillin(PEN), and tetracycline(TET) was 96.90%, 96.27%, and 96.65%, respectively. The rate of decreased susceptibility of NG against ceftriaxone(CRO) and cefixime(CFM) was 9.32% and 9.94%, respectively. The susceptibility rates of UU and MH against minocycline(MIN), doxycycline(DOX) and josamycin(JOS) were more than 90%. Conclusion The infection rate of simple UU ranked the first, followed by simple NG. The third-generation cephalosporins such as CRO and CFM remained the first-line therapy for NG infections, and MIN, DOX and JOS were effective antibiotics for UU and MH infections.

关 键 词：男性 泌尿生殖道 病原体 感染 耐药性 泰安 

分 类 号：R446.5[医药卫生—诊断学]