电化学N-酰化醛缩合制备酰胺  

Electrochemical N-acylation Synthesis of Amides from Aldehydes

作　　者：张辉先 王启化 王博[1] ZHANG Hui-xian;WANG Qi-hua;WANG Bo(College of Chemical Engineering and Technology,Hainan University,Haikou 570228,China;Shanxian horticultural Community Health Service Center,Heze 274300,China)

机构地区：[1]海南大学化学工程与技术学院,海南海口570228 [2]山东省单县园艺社区卫生服务中心,山东菏泽274300

出　　处：《合成化学》2021年第3期191-199,共9页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(ZZZZ002023384)。

摘　　要：通过电化学辅助碘化钾催化系列醛和系列胺一锅法高效合成酰胺,该方法操作简便,反应条件温和,无需氧化剂、电解质、强碱、保护气体及贵金属催化剂,在常温常压条件下分别使用Cu-Pt为阴阳电极以甲醇为溶剂恒压6 V反应12 h即可顺利催化各类醛合成多种芳基、烷基酰胺,多数产物都有较高产率,最高达93%。An efficient one pot method for the synthesis of amides from aldehydes and amines catalyzed by potassium iodide and electrochemistry is reported.This method was easy to operate in mild reaction conditions,without additional oxidants,electrolytes,strong bases,shielding gases and precious metal catalysts.Under the conditions of constant temperature and pressure,the various aldehydes could be successfully catalyzed by using Cu and Pt as the cathode and anode and constant current=6 V in methanol for 12 h.Most of the products had high yield,up to 93%.

关 键 词：电化学 碘化钾 室温 醛 酰胺 合成 

分 类 号：O625.4[理学—有机化学]