甲硝唑药物锰配合物的合成及与DNA的相互作用  

Synthesis and DNA Interaction of A Manganese Complex with Metronidazole Drug

作　　者：杨莉宁[1] 黑嘉慧 成昭[1] 苗延青[1] YANG Li-ning;HEI Jia-hui;CHENG Zhao;MIAO Yan-qing(Department of Pharmacy,Medical University of Xi’an,Xi’an 710021,China;Shaanxi Aerospace Staffs&Vocation University,Xi’an 710100,China)

机构地区：[1]西安医学院药学院,陕西西安710021 [2]陕西航天职工大学,陕西西安710100

出　　处：《合成化学》2021年第3期208-213,共6页Chinese Journal of Synthetic Chemistry

基　　金：陕西省自然科学基金研究计划(2019JQ068);陕西省大学生创新创业训练计划项目(S202011840060);西安医学院校级项目(2018PT62)。

摘　　要：以甲硝唑与二价锰盐为原料合成了锰(Ⅱ)配合物[Mn_(2)(C_(6)H_(9)O_(3)N_(3))_(2)(Ac)_(4)(H_(2)O)_(2)]·6H_(2)O,并根据元素分析、IR、UV-Vis、电导率及热失重等方法对配合物进行了性质表征和结构推测。利用光谱分析法及黏度法分析对比了配体甲硝唑及其金属锰配合物与小牛胸腺DNA(ct-DNA)的相互作用,结果表明二者皆以插入方式与DNA相互作用,配体作用力强于配合物。The manganese complex of metronidazole[Mn_(2)(C_(6)H_(9)O_(3)N_(3))_(2)(Ac)_(4)(H_(2)O)_(2)]·6H_(2)O was synthesized by metronidazole and divalent metal manganese salt,and the properties and possible structure of the complex was characterized by elemental analysis,UV-Vis spectral,infrared spectral,conductivity and thermogravimetric analysis.The interaction of metronidazole and the complexe with calf thymus DNA was examined using spectral analysis and viscosity studies to understand the mode and extent of DNA binding.DNA interaction studies indicated intercalation as probable mode of interaction.The interaction of metronidazole is stronger than the complex.

关 键 词：甲硝唑 锰(Ⅱ)配合物 DNA相互作用 合成 小牛胸腺DNA 

分 类 号：O614[理学—无机化学]