全身动脉粥样硬化斑块与脑梗死的关系:北京血管病变评价研究结果  

Relationship Between Systemic Atherosclerotic Plaques and Cerebral Infarction:Results from Beijing Vascular Disease Evaluation Study

作　　者：张颖怡 刘金波[1,2] 刘欢 赵娜[1,2] 赵红薇 王宏宇 ZHANG Yingyi;LIU Jinbo;LIU Huan;ZHAO Na;ZHAO Hongwei;WANG Hongyu(Department of Vascular Medicine,Peking University Shougang Hospital,Beijing 100144,China;Vascular Health Research Center of Peking University Health Science Center,Beijing 100144,China;Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education(Peking University),Beijing 100191,China)

机构地区：[1]北京大学首钢医院血管医学中心,北京100144 [2]北京大学医学部血管健康研究中心,北京100144 [3]分子心血管学教育部重点实验室(北京大学),北京100191

出　　处：《心血管病学进展》2021年第3期277-284,共8页Advances in Cardiovascular Diseases

基　　金：教育部科技发展中心产学研创新基金——“智融兴教”基金(2018A02004);2019年度北京大学首钢医院院内科研项目(SGYYQ201912);2019年度临床重点项目建设项目(2019-Yuan-LC-01);2020年首都卫生发展科研专项(自主创新)(首发2020-2-6042)。

摘　　要：目的探讨全身动脉粥样硬化斑块与脑梗死的关系。方法本研究纳入411例患者[(66.3±13.5)岁,男性52.9%],均进行全身血管超声检查。使用逻辑回归评估全身动脉粥样硬化斑块累及血管床数目、斑块部位与脑梗死的关系。结果脑梗死组的3~5个部位斑块检出率和颈动脉合并其他部位斑块检出率高于无脑梗死组,伴随白介素-6和心-踝血管指数的明显升高。在未调整的模型中,3~5个部位粥样硬化斑块组、颈动脉合并其他部位粥样硬化斑块组发生脑梗死风险分别是无斑块组的2.595倍(95%CI 1.338~5.031,P<0.01)和2.551倍(95%CI 1.317~4.942,P<0.01)。调整了性别和年龄后,斑块累及血管床数目和斑块部位与脑梗死的关系不显著。结论在未调整的模型中,与无斑块组相比,3~5个部位血管床粥样硬化斑块组和颈动脉合并其他部位粥样硬化斑块组发生脑梗死的风险更高。Objective We aimed to clarify the relationship between systemic atherosclerotic plaques and cerebral infarction.Methods The study included a total of 411 patients[(66.3±13.5)years of age,52.9%of men]into the study.All the subjects underwent a systemic vascular ultrasound examination.The relationship between the number of vascular beds affected,the plaque site and cerebral infarction was assessed using logical regression.Results The detection rate of plaques in 3~5 sites and plaques in the carotid artery with other arteries were higher in the cerebral infarction group than that in non-cerebral infarction group,with a significant increase in the level of interleukin-6 and cardio-ankle vascular index.In the unadjusted model,the risk of stroke was 2.595 times(95%CI 1.338~5.031,P<0.01)and 2.551 times(95%CI 1.317~4.942,P<0.01)higher in the atherosclerotic plaque group at 3~5 sites and in the carotid artery with other atherosclerotic plaque sites than that in the non-atherosclerotic plaque group.After Adjusted for sex and age,this relationship was not significant.Conclusion In unadjusted models,the risk of cerebral infarction was higher in atherosclerotic plaque group of 3~5 sites and carotid artery with other arteries than that in non-atherosclerotic plaque group.

关 键 词：脑梗死 动脉粥样硬化 斑块 炎症 

分 类 号：R74[医药卫生—神经病学与精神病学]