S100A8/A9在预测冠状动脉病变及其严重程度中的临床价值  

Clinical value of S100A8/A9 in predicting coronary artery lesions and their severity

作　　者：尹毓瑶 刘艳莉 张新鑫 王潇[1] 潘一龙[1] 李晓东[1] Yin Yuyao;Liu Yanli;Zhang Xinxin;Wang Xiao;Pan Yilong;Li Xiaodong(First Department of Cardiovascular Medicine,Shengjing Hospital,China Medical University,Shenyang 110004,China;不详)

机构地区：[1]中国医科大学附属盛京医院第一心血管内科,沈阳110004

出　　处：《中国循证心血管医学杂志》2021年第3期293-297,共5页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：“十二五”国家科技支撑计划(2014BAL11B04)。

摘　　要：目的分析S100A8/A9蛋白水平对预测冠状动脉(冠脉)病变及其严重程度中的临床价值。方法选取在2019年3月至2020年5月间就诊于中国医科大学附属盛京医院行冠脉造影术的患者225例,根据造影结果分为冠脉病变组(147例)和对照组(78例)。根据SYNTAX评分和Gensini评分评估患者冠脉病变的严重程度。使用SYNTAX评分将冠脉病变组分为轻度冠脉病变组(92例),中度冠脉病变组(33例)和重度冠脉病变组(22例)。使用Gensini评分将患者分为轻微冠脉病变组(89例)和严重冠脉病变组(58例)。收集患者血液样本检测S100A8/A9蛋白水平。结果存在冠脉病变患者的S100A8/A9水平明显高于健康人[0.86(0.37~1.47)vs.0.30(0.22~0.45)μg/ml,P<0.001]。S100A8/A9蛋白是出现冠脉病变的独立危险因素[OR=18.58(5.29~65.18),P<0.001]。S100A8/A9浓度和SYNTAX评分具有正相关性(r=0.786,P<0.001)。S100A8/A9水平随病变严重程度加重逐渐升高。轻度病变与中、重度病变存在统计学差异(P<0.001),而中度病变与重度病变之间无显著差异(P=0.030)。S100A8/A9浓度和Gensini评分间具有正相关性(r=0.746,P<0.001)。根据ROC曲线结果得出血清S100A8/A9水平超过0.86μg/mL时认为患者可能存在严重冠脉病变的风险,此时灵敏度0.897,特异度0.775。结论S100A8/A9水平在有冠脉病变的患者中显著升高,是其独立危险因素。S100A8/A9水平与冠脉病变严重程度相关,对严重冠脉病变有较好的预测价值。Objective To analyze the clinical value of S100A8/A9 protein level in predicting coronary artery lesions(CAL)and their severity.Methods The patients(n=225)undergone coronary angiography(CAG)were chosen from Shengjing Hospital affiliated to China Medical University from Mar.2019 to May 2020,and divided,according to CAG results,into CAL group(n=147)and control group(n=78).CAL severity was reviewed respectively according to SYNTAX scores and Gensini scores.According to SYNTAX scores,the patients were divided into mild CAL group(n=92),moderate CAL group(n=33)and severe CAL group(n=22).According to Gensini scores,the patients were divided into slight CAL group(n=89)and serious CAL group(n=58).The blood samples were collected for detecting S100A8/A9 protein level.Results The level of S100A8/A9 protein was significantly higher in CAL group than that in control group[0.86,(0.37~1.47)μg/ml vs.0.30(0.22~0.45)μg/ml,P<0.001].S100A8/A9 protein was an independent risk factor of CAL[OR=18.58(5.29~65.18),P<0.001].The level of S100A8/A9 protein was positively correlated to SYNTAX scores(r=0.786,P<0.001).The level of S100A8/A9 protein increased gradually along with CAL severity exacerbated.There was statistical difference among mild CAL group,moderate CAL group and severe CAL group(P<0.001),and there was no significant difference between moderate CAL group and severe CAL group(P=0.030).The level of S100A8/A9 protein was positively correlated to Gensini scores(r=0.746,P<0.001).The results of ROC curve analysis showed that when S100A8/A9 protein level was higher over 0.86μg/ml,patients had higher CAL risks,and sensitivity was 0.897 and specificity was 0.775.Conclusion The level of S100A8/A9 protein will increase significantly in CAL patients,which is an independent risk factor and closely correlated to CAL severity.The level of S100A8/A9 protein has a higher predictive value to severe CAL.

关 键 词：S100A8/A9 冠脉病变 SYNTAX评分 GENSINI评分 

分 类 号：R543.3[医药卫生—心血管疾病]