生物碱抗心律失常的作用及其分子机制  

The Role and Mechanisms of Alkaloids on Anti-arrhythmia

作　　者：吴美芳[1] 沈瑞池[1] 王杰[1] WU Mei-fang;SHEN Rui-chi;WANG Jie(Fujian Institute of Subtropical Botany/Fujian Key Laboratory of Subtropical Plant Physiology and Biochemistry,Xiamen 361006,Fujian China)

机构地区：[1]福建省亚热带植物研究所/福建省亚热带植物生理生化重点实验室,福建厦门361006

出　　处：《亚热带植物科学》2020年第6期490-499,共10页Subtropical Plant Science

基　　金：厦门市科技扶贫项目(3502Z20194507);厦门市重大科技创新平台项目(3502Z20131004)。

摘　　要：生物碱是广泛存在于生物体内尤其是天然植物中的碱性含氮有机化合物,部分生物碱具有抗心律失常、抗高血压、抗炎以及抗肿瘤等多种生理功能。心律失常是由心脏电生理活动紊乱引起的疾病,是心血管疾病高发病率和死亡率的主要原因,在世界范围内严重威胁人类生命健康。文中综述生物碱在抗心律失常中的作用和分子机制研究进展,并展望其开发应用前景。Alkaloids are nitrogen-containing organic compounds widely existing in organisms, especially in plants. Some alkaloids have a variety of physiological functions such as anti-arrhythmia, anti-hypertension, anti-inflammation and anti-tumor. Arrhythmia is a disease caused by abnormal electrophysiological activity in the heart rate or rhythm. It is the major cause of high cardiovascular morbidity and mortality. It is a serious threat to human health and lives in the worldwide. This paper reviewed the recent progress about the role and mechanisms of alkaloids on anti-arrhythmia. In addition, the development and utilization prospect of alkaloids were introduced.

关 键 词：生物碱 心律失常 苦参碱类生物碱 莲心碱 离子通道 

分 类 号：R966[医药卫生—药理学]