Co-solvent polarity controlled self-assembly of tetraphenylethylene-buried amphiphile for size-regulated tumor accumulation  

作　　者：Jingsheng Huang Yun Chen Pengxiang Zhao Yunlong Yu Shiyong Zhang Zhongwei Gu 

机构地区：[1]National Engineering Research Center for Biomaterials,Sichuan University,29 Wangjiang Road,Chengdu 610064,China [2]Science and Technology on Surface Physics and Chemistry Laboratory,Mianyang 621907,China [3]College of Materials Science and Engineering,Nanjing Tech University,Nanjing,Jiangsu 210009,China

出　　处：《Regenerative Biomaterials》2018年第5期275-282,共8页再生生物材料（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21372170 and 51703145);the Excellent Young Foundation of Sichuan Province(2016JQ0028);Applied Basic Research Project of Sichuan Province(15JC0440);the Discipline Development Foundation of Science and Technology on Surface Physics and Chemistry Laboratory(Nos.XKFZ201505 and XKFZ201506).

摘　　要：We report that the co-solvent polarity can precisely control the TPE-buried amphiphile 1 to selfassemble into nanoparticles(NPs)in water with size range from21–32nm to 55–68nm to 95–106 nm.Excepted for size,these TPE-buried amphiphile fabricated NPs hold identical physical properties such as spherical shape,surface charge,and luminescent properties,and moreover,after covalent capture of the acrylate hydrophilic heads,the resulting cross-linked NPs(cNPs I–III)own excellent in vivo stability,which thus would be an ideal platform for investigating the size effects on tumor accumulation and penetration.

关 键 词：polarity control aggregation-induced emission size regulation tumor accumulation 

分 类 号：TQ3[化学工程]