In vitro and in vivo degradation behavior of poly(trimethylene carbonate-co-D,L-lactic acid)copolymer  

作　　者：Zhengyu Ma Yi Wu Jing Wang Changsheng Liu 

机构地区：[1]Engineering Research Center for Biomedical Materials of Ministry of Education,School of Materials Science and Engineeering,East China University of Science and Technology,Shanghai 200237,People’s Republic of China [2]The State Key Laboratory of Bioreactor Engineering,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,People’s Republic of China [3]Key Laboratory for Ultrafine Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,People’s Republic of China

出　　处：《Regenerative Biomaterials》2017年第4期207-213,共7页再生生物材料（英文版）

基　　金：The authors would like to express their gratitude to the National Natural Science Foundation of China(No.31330028,31470923,31271011);National Basic Research Program of China(973 Program,No.2012CB933600),the 111 Project(B14018);New Century Excellent Talents in University(No.NCET-12-0856);This study is also supported by Major Basic Research Foundation of Shanghai Science and Technique Committee(14JC1490800).

摘　　要：We present P(TMC-co-DLLA)copolymer with the molar ratio of TMC:DLLA紏15:85 was used to systematic study of in vivo and in vitro degradation behaviors.Dense homogeneous copolymer specimens were prepared by compression molding method.The in vitro and in vivo degradation were,respectively,performed at simulative body condition and implanted into rat’s subcutaneous condition.Investigations were followed via physicochemical and histological analysis such as SEM,GPC,DSC,FTIR and H&E stain.The results demonstrate that copolymeric material can degrade in phosphate buffer solution(PBS)and in rat’s body,and the in vivo degradation rate is faster.Obvious decline of molecule weight and mass loss has been observed,which led to the attenuation of mechanical strength.Furthermore,apart from the hydrolysis,macrophagocytes took part in the phagocytosis in vivo,indicating that degradation rate could be regulated by the combinational mechanism.It is concluded that P(TMC-co-DLLA)copolymer is a promising candidate for tissue repair.

关 键 词：P(TMC-co-DLLA) COPOLYMER DEGRADATION tissue repair 

分 类 号：O63[理学—高分子化学]