1例猫假足菌肿的诊断与治疗  

Diagnosis and Treatment of Feline Dermatophytic Pseudomycetoma

作　　者：缴莹 季玲西 黄薇 肖盟 吕艳丽[1] JIAO Ying;JI Lingxi;HUANG Wei;XIAO Meng;LYU Yanli(Veterinary Teaching Hospital,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China;Beijing Key Laboratory for Mechanisms Research and Pricision Diagnosis of Invasive Fungal Diseases, Department of Clinical Laboratory,Peking Union Medical College Hospital, Chinese Academy of Medical Sciences,Beijing 100730, China)

机构地区：[1]中国农业大学动物医学院,动物医院,北京100193 [2]中国医学科学院北京协和医院检验科,侵袭性真菌病机制研究与精准诊断北京市重点实验室,北京100730

出　　处：《中国畜牧兽医》2021年第3期1141-1147,共7页China Animal Husbandry & Veterinary Medicine

基　　金：北京市科技计划项目(Z171100001517008)。

摘　　要：为加强对罕见疾病假足菌肿的认识,给兽医工作者在诊治相似病例时提供参考,本研究分别从临床症状、诊断过程及治疗方法对1例犬小孢子菌引起的猫假足菌肿的病例进行报道。采集患猫尾荐部样本进行细胞学检查、真菌培养及菌株质谱鉴定。细胞学涂片中可见大量的炎性细胞、真菌孢子和真菌菌丝,诊断为真菌性肉芽肿性炎症。基于细胞学的结果,取样进行真菌培养。对培养出的菌株染色镜检,发现有6个以上分隔的大分生孢子。最后,通过质谱鉴定确定该病原菌为犬小孢子菌。综合以上检查结果,该病例诊断为犬小孢子菌引起的猫假足菌肿。治疗采用外用药浴与口服抗真菌药物相结合的方法。治疗初期,患猫尾部病灶有好转但并不明显,后期持续恶化,并于首诊后7个月死亡,主要死亡原因不明。建议兽医工作者在遇到相似病例时引起重视,采用细胞学检查、真菌培养及菌株鉴定等方法进行综合诊断。在疾病早期使用手术切除与抗真菌药物相结合的方法进行治疗,以提高患病动物的存活率。The objective of this study was to report one case of the feline pseudomycetoma infected by Microsporum canis,from clinical symptom,diagnostic process to treatment strategies,which might strengthen awareness to the disease and provide potential insights for veterinary clinicians.Samples from the tail were taken for cytological examination,fungal culture and identification with MALDI-TOF MS.A large number of inflammatory cells,fungal spores and hyphae were observed in the cytology smear which indicated granulomatous inflammation.Based on the above results,fungal culture was performed.Staining and microscopic examination revealed more than six separated macroconidia in the cultured strains,which was finally identified as Microsporum canis by MALDI-TOF MS.In conclusion,the case was diagnosed as feline dermatophytic pseudomycetoma caused by Microsporum canis.Treatment for this case included shampoos and oral antifungal agents.In the early stage,the tail lesion was slightly improved and continued to deteriorate in the later stage.The patient died 7 months later with unknown reason.It suggested that veterinarians should pay attention when they encounter similar cases and use cytological examination,fungal culture and strain identification for diagnosis.Surgical removal in conjunction with medical therapy could improve the survival rate of the patient in the early stage of this disease.

关 键 词：猫 皮肤癣菌性假足菌肿 诊断 治疗 

分 类 号：S854[农业科学—临床兽医学]