Properties of carbon nanotube-dispersed Sr-hydroxyapatite injectable material for bone defects  

作　　者：M.G.Raucci M.Alvarez-Perez D.Giugliano S.Zeppetelli L.Ambrosio 

机构地区：[1]Institute of Polymers,Composites and Biomaterials,National Research Council of Italy,Mostra D’oltremare Pad.20-Viale Kennedy 54,Naples 80125,Italy [2]Tissue Bioengineering Laboratory,DEPeI,Faculty of Dentistry,National Autonomous University of Mexico,Mexico DF 04510,Mexico [3]Department of Chemical Sciences and Materials Technology,National Research Council of Italy,(DSCTM-CNR),P.Le Aldo Moro 7,Rome 00185,Italy

出　　处：《Regenerative Biomaterials》2016年第1期13-23,共11页再生生物材料（英文版）

基　　金：supported through funds provided by the PNR-CNR Aging Program 2012-2014.

摘　　要：This study concerns the synthesis of gel materials based on carbon nanotubes dispersed strontium-modified hydroxyapatite(Sr-HA)at different compositions obtained by sol–gel technology and their influence on human-bone-marrow-derived mesenchymal stem cells.Furthermore,an evaluation of the influence of nanotubes and Strontium on physico-chemical,morphological,rheological and biological properties of hydroxyapatite gel was also performed.Morphological analysis(scanning electron microscopy)shows a homogeneous distribution of modified nanotubes in the ceramic matrix improving the bioactive properties of materials.The biological investigations proved that Sr-HA/carbon nanotube gel containing 0–20 mol(%)of Sr showed no toxic effect and promote the expression of early and late markers of osteogenic differentiation in cell culture performed in basal medium without osteogenic factors.Finally,the SrHA/carbon nanotube gels could have a good potential application as filler in bone repair and regeneration and may be used in the osteoporotic disease treatment.

关 键 词：NANOBIOMATERIALS sol-gel tecnology biomaterial-cell interaction BIOCERAMICS bone tissue engineering 

分 类 号：TB3[一般工业技术—材料科学与工程]