老年股骨颈骨折人工股骨头置换术后迈之灵片和鲑鱼降钙素联合应用的临床疗效  

Clinical effect of combined application of Maizhiling tablets and salmon calcitonin after artificial femoral head replacement in elderly patients with femoral neck fracture

作　　者：李旻 王娜 蒋雨宸 冯林杰 平少华 Li Min;Wang Na;Jiang Yuchen;Feng Linjie;Ping Shaohua(Department of Orthopedics,Affiliated Hospital of North China University of Science and Technology,Tangshan 063000,China;Department of Otolaryngology,Affiliated Hospital of North China University of Science and Technology,Tangshan 63000,China)

机构地区：[1]华北理工大学附属医院骨科,河北省唐山市063000 [2]华北理工大学附属医院耳鼻喉科,河北省唐山市063000

出　　处：《中国综合临床》2021年第2期154-160,共7页Clinical Medicine of China

基　　金：河北省医学科学研究课题计划(20191152);华北理工大学科学研究基金项目(Z201538)。

摘　　要：目的探讨老年股骨颈骨折人工股骨头置换术后应用迈之灵片联合鲑鱼降钙素治疗的临床效果和术后6个月患髋关节功能的影响因素。方法采用前瞻性研究方法,收集华北理工大学附属医院于2017年1月至2019年6月行人工股骨头置换术治疗的老年股骨颈骨折患者84例,用随机数字表法分为治疗组(41例)和对照组(43例)。治疗组应用迈之灵片和鲑鱼降钙素鼻喷剂加基础钙剂治疗;对照组给予基础钙剂治疗。采用独立样本t检验比较两组患者术后第5天疼痛视觉模拟评分(visual analogue score,VAS)、大腿部淤血完全消退时间、术后初次下地活动时间。采用重复测量方差分析比较两组患者术后14 d、3个月、6个月的健侧股骨颈骨密度值及患髋关节功能的Harris评分。采用多因素Logistic回归分析术后6个月患侧髋关节功能的影响因素。结果术后第5天VAS评分:治疗组为(6.34±1.54)分,对照组为(7.02±1.50)分;大腿部淤血完全消退时间:治疗组为(12.12±2.27)d,对照组为(13.88±2.58)d;术后初次下地活动时间:治疗组为(5.93±1.52)d,对照组为(7.84±1.05)d;两组患者上述各指标比较差异均有统计学意义(t值分别为2.051、3.313、6.673,P均<0.05)。治疗组患者在术后14 d及术后3、6个月健侧股骨颈骨密度值分别为(0.543±0.123)、(0.561±0.119)、(0.606±0.105)g/cm2,对照组分别为(0.530±0.092)、(0.517±0.089)、(0.526±0.090)g/cm2;重复测量的方差分析结果表明,F组内=55.726、P<0.01,F组间=4.206、P<0.05,F交互=57.654、P<0.01;治疗组术后3、6个月与组内术后14 d比较差异均有统计学意义(P均<0.01),术后3个月与术后6个月比较差异有统计学意义(P<0.01);对照组术后14 d与组内术后3个月比较差异有统计学意义(P<0.01),术后3个月与术后6个月比较差异有统计学意义(P<0.01);术后6个月组间比较差异有统计学意义(P<0.01)。治疗组患者在术后14 d、3个月、6个月患髋关节Harris�Objective To study the clinical effect of Maizhiling tablets combined with salmon calcitonin in the treatment of elderly femoral neck fracture after artificial femoral head replacement and the influencing factors of hip joint function 6 months after operation.Methods Prospective research methods were used in this article.A total of 84 elderly patients with femoral neck fracture who underwent artificial femoral head replacement in the Affiliated Hospital of North China University of Science and Technology from January 2017 to June 2019 were selected and randomly divided into the treatment group(41 cases)and the control group(43 cases)by the random number table method.The treatment group was treated with Maizhiling tablet and salmon calcitonin nasal spray plus basic calcium;the control group was treated with basic calcium.Independent sample t test was used to compare the visual analogue score(VAS)on the 5th day after operation,the time of complete disappearance of congestion in thigh,and the time of first ambulation after operation between the two groups.The bone mineral density(BMD)of contralateral femoral neck and Harris score of hip joint function were compared between the two groups at 14 days,3 months and 6 months after operation by repeated measurement variance analysis.Multivariate Logistic regression was used to analyze the influencing factors of hip joint function at 6 months after operation.Results VAS score on the 5th day after surgery:(6.34±1.54)points in the treatment group and(7.02±1.50)points in the control group.Complete regression time of thigh congestion:(12.12±2.27)d in the treatment group and(13.88±2.58)d in the control group.The first postoperative activity time was(5.93±1.52)d in the treatment group and(7.84±1.05)d in the control group,and the differences of the above indexes between the two groups were statistically significant(t value was 2.051,3.313,6.673,respectively,all P<0.05).The BMD values of the contralateral femoral neck in the treatment group were(0.543±0.123),(0.561±0.119),

关 键 词：股骨颈骨骨折 人工股骨头置换术 迈之灵片 鲑鱼降钙素 老年人 

分 类 号：R687.3[医药卫生—骨科学]