Drug carriers based on highly protein-resistant materials for prolonged in vivo circulation time  

作　　者：Ruiyuan Liu Yan Li Zhenzhong Zhang Xin Zhang 

机构地区：[1]National Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Science,Beijing 100190,People’s Republic of China [2]School of Pharmaceutical Sciences,Zhengzhou University,100 Kexue Avenue,Zhengzhou 450001,People’s Republic of China [3]University of Chinese Academy of Sciences,Beijing 100049,People’s Republic of China

出　　处：《Regenerative Biomaterials》2015年第2期125-133,共9页再生生物材料（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(21304099,51203162,51103159,51373177);the National High Technology Research and Development Program(2014AA020708,2012AA022703,2012AA020804);the Instrument Developing Project of the Chinese Academy of Sciences(YZ201253,YZ201313);the Open Funding Project of the National Key Laboratory of Biochemical Engineering(Y22504A169);the‘Strategic Priority Research Program’of the Chinese Academy of Sciences(XDA09030301-3);Beijing Natural Science Foundation(Z141100000214010).

摘　　要：Long-circulating drug carriers are highly desirable in drug delivery system.However,nonspecific protein adsorption leaves a great challenge in drug delivery of intravenous administration and significantly affects both the pharmacokinetic profiles of the carrier and drugs,resulting in negatively affect of therapeutic efficiency.Therefore,it is important to make surface modification of drug carriers by protein-resistant materials to prolong the blood circulation time and increase the targeted accumulation of therapeutic agents.In this review,we highlight the possible mechanism of protein resistance and recent progress of the alternative protein-resistant materials and their drug carriers,such as poly(ethylene glycol),oligo(ethylene glycol),zwitterionic materials,and red blood cells adhesion.

关 键 词：long circulation nonspecific protein adsorption materials drug carrier surface modification 

分 类 号：O63[理学—高分子化学]