Surface modification of biodegradable magnesium and its alloys for biomedical applications  

作　　者：Peng Tian Xuanyong Liu 

机构地区：[1]State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,PR China

出　　处：《Regenerative Biomaterials》2015年第2期135-151,共17页再生生物材料（英文版）

基　　金：This work is jointly financially supported from the National Basic Research Program of China(973 Program,2012CB933600);National Natural Science Foundation of China(81271704);Shanghai Science and Technology R&D Fund under grant 11JC1413700 and 14XD1403900.

摘　　要：Magnesium and its alloys are being paid much attention recently as temporary implants,such as orthopedic implants and cardiovascular stents.However,the rapid degradation of them in physiological environment is a major obstacle preventing their wide applications to date,which will result in rapid mechanical integrity loss or even collapse of magnesium-based implants before injured tissues heal.Moreover,rapid degradation of the magnesium-based implants will also cause some adverse effects to their surrounding environment,such as local gas cavity around the implant,local alkalization and magnesium ion enrichment,which will reduce the integration between implant and tissue.So,in order to obtain better performance of magnesium-based implants in clinical trials,special alloy designs and surface modifications are prerequisite.Actually,when a magnesium-based implant is inserted in vivo,corrosion firstly happens at the implant-tissue interface and the biological response to implant is also determined by the interaction at this interface.So the surface properties,such as corrosion resistance,hemocompatibility and cytocompatibility of the implant,are critical for their in vivo performance.Compared with alloy designs,surface modification is less costly,flexible to construct multi-functional surface and can prevent addition of toxic alloying elements.In this review,we would like to summarize the current investigations of surface modifications of magnesium and its alloys for biomedical application.The advantages/disadvantages of different surface modification methods are also discussed as a suggestion for their utilization.

关 键 词：magnesium alloys surface modification coatings ion implantation BIODEGRADABILITY BIOCOMPATIBILITY 

分 类 号：TG1[金属学及工艺—金属学]