Multifunctional mussel-inspired copolymerized epigallocatechin gallate(EGCG)/arginine coating:the potential as an ad-layer for vascular materials  

作　　者：Rifang Luo Linlin Tang Lingxia Xie Jin Wang Nan Huang Yunbing Wang 

机构地区：[1]National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610064,China [2]Key Lab of Advanced Technology of Materials of Education Ministry,Southwest Jiaotong University,Chengdu 610031,China

出　　处：《Regenerative Biomaterials》2016年第4期247-255,共9页再生生物材料（英文版）

基　　金：The author would like to thank Dr Manfred.F.Maitz for his selfless assistance of this job and appreciate Mr Chongxi Jiang and Mrs Ru Shen for their help and contributions on sample characterization and analysis.Specially thank Miss Si Zhong and Mr Xin Wang for their help of cell compatibility evaluation.This work was supported by Natural Science Foundation of China(Grant 51173149,81330031 and 31270020);Sichuan Province Science and Technology Support Program(No.2014SZ0128);the 111 Project.The Program of Introducing Talents of Discipline to Universities(B16033).

摘　　要：Surface properties are considered to be important factors in addressing proper functionalities.In this paper,a multifunctional mussel-inspired coating was prepared via the direct copolymerization of epigallocatechin gallate(EGCG)and arginine.The coating formation was confirmed by X-ray photoelectron spectroscopy and Fourier transform infrared spectra.The EGCG/arginine coating contained diverse functional groups like amines,phenols and carboxyls,whose densities were also tunable.Such mussel-inspired coating could also be applied as an ad-layer for its secondary reactivity,demonstrated by quartz crystal microbalance technique.Moreover,the tunable surface density of phenols showed potential ability in modulating endothelial cell and smooth muscle cell viability.The coatings rich in phenols presented excellent free radical scavenging property.Current results strongly indicated the potential of EGCG/arginine coatings to be applied as an ad-layer for vascular materials.

关 键 词：Mussel chemistry epigallocatechin gallate(EGCG) vascular devices surface modification MULTIFUNCTION 

分 类 号：TG1[金属学及工艺—金属学]