毛细管电泳-荧光检测在药物分析中的应用  

Application of Capillary Electrophoresis-Fluorescence Detection for Pharmaceutical Analysis

作　　者：洪婷婷 周舒文[1] 崔朋飞 邱琳[1] 蒋鹏举[1] 王建浩[1] HONG Tingting;ZHOU Shuwen;CUI Pengfei;QIU Lin;JIANG Pengju;WANG Jianhao(School of Pharmacy,Changzhou University,Changzhou 213164,China)

机构地区：[1]常州大学药学院,江苏常州213164

出　　处：《常州大学学报（自然科学版）》2021年第2期68-72,共5页Journal of Changzhou University：Natural Science Edition

基　　金：国家自然科学基金资助项目(81803495)。

摘　　要：毛细管电泳微分离技术基于其样品用量少,分离效率高的特点,在分离分析领域具有其独特的优势。相较于传统紫外检测,毛细管电泳-荧光检测可实现高灵敏度的分析。围绕药物分析的应用,着重介绍了毛细管电泳-荧光检测技术用于手性药物的分离、化学及生物药物的定量分析以及抑制剂的筛选。Capillary electrophoresis technique presents tremendous advantages in separation science depending on its high efficiency and low sample consumption.Compared with traditional ultraviolet detection,capillary electrophoresis-fluorescence detection can achieve high sensitivity.This review mainly introduces the application of capillary electrophoresis-fluorescence detection for chiral separation,quantification of chemical and biological drugs and screening inhibitors.

关 键 词：毛细管电泳 荧光检测 药物分析 

分 类 号：R9[医药卫生—药学]