Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release  

作　　者：Teng-Teng Cai Qi Lei Bin Yang Hui-Zhen Jia Hong Cheng Li-Han Liu Xuan Zeng Jun Feng Ren-Xi Zhuo Xian-Zheng Zhang 

机构地区：[1]Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry,Wuhan University,Wuhan 430072,China

出　　处：《Regenerative Biomaterials》2014年第1期27-35,共9页再生生物材料（英文版）

基　　金：This work was supported by the National Key Basic Research Program of China(2011CB606202);National Natural Science Foundation of China(Grant Nos.21374085,21174110 and 51303137);the Fundamental Research Funds for the Central Universities(2042014kf0193).

摘　　要：A novel Uralic(U)-rich linear-hyperbranched mono-methoxy poly(ethylene glycol)-hyperbranched polyglycerol-graft-Uralic(mPEG-HPG-g-U)nanoparticle(NP)was prepared as drug carrier for antitumor methotrexate(MTX).Due to the H-bond interaction of U with MTX and hydrophobic interaction,this NP exhibited high drug loading efficiency of up to 40%,which was significantly higher than that of traditional NPs based on U-absent copolymers(<15%).In addition,MTX-loaded mPEG-HPG-g-U NPs also demonstrated an acidity-accelerated drug release behavior.

关 键 词：nucleobase Uralic H-bond interaction linear-hyperbranched copolymer drug loading efficiency PH-SENSITIVITY 

分 类 号：O63[理学—高分子化学]