Clinical evaluation following the use of mineralized collagen graft for bone defects in revision total hip arthroplasty  

作　　者：Cheng Huang Liwu Qin Wei Yan Xisheng Weng Xiangjie Huang 

机构地区：[1]Department of Orthopaedics,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [2]Department of Orthopaedics,Wendeng Orthopaedic Hospital of Shandong Province Affiliated to Shandong University of Traditional Chinese Medicine,Weihai 264400,China

出　　处：《Regenerative Biomaterials》2015年第4期245-249,共5页再生生物材料（英文版）

基　　金：This work was partly supported by National Basic Research Program(973 Program)of China(2011CB606205);‘Twelfth Five-Year’National Science and Technology Support Program(2012BAI17B02)funded by the Ministry of Science and Technology of China,and the National Natural Science Foundation of China(21371106,51402167);Shandong province science and technology development program(2013GGA10036).Conflict of interest statement.None declared.

摘　　要：Revision total hip arthroplasty(THA)with massive bone loss has been a real challenge for orthopaedic surgeons.Here we describe an approach using mineralized collagen(MC)graft to reconstruct acetabulum and femur with massive bone defects.We identified 89 patients suffering acetabular or femoral bone defects after primary THA,who required revision THA for this study.During the surgery,MC was applied to reconstruct both the acetabular and femoral defects.Harris hip score was used to evaluate hip function while radiographs were taken to estimate bone formation in the defect regions.The average follow-up period was 33.662.4 months.None of the components needed re-revised.Mean Harris hip scores were 42.563.5 before operation,75.264.0 at 10th month and 95.063.6 at the final follow-up.There were no instances of deep infection,severe venous thrombosis or nerve palsy.The present study demonstrated that MC graft can serve as a promising option for revision THA with massive bone deficiency.Meanwhile,extended follow-up is needed to further prove its long-term performance.

关 键 词：total hip arthroplasty REVISION bone defect mineralized collagen bone substitutes 

分 类 号：R68[医药卫生—骨科学]