吸烟与阿兹海默症关联性的meta分析  

Meta analysis of the association between smoking and Alzheimer’s disease

作　　者：梁丽明 陈文智 于德娥 白树堂[1] 符洪犊[1] LIANG Li-ming;CHEN Wen-zhi;YU De-e;BAI Shu-tang;FU Hong-du(Department of Cardiac Surgery,Hoikou Ajfilialed Hospital of Central South University Xiangya School of Medicine,Haikou Hainan,510208,China;Department of Environmental Health and Occupational Medicine,School of Public Health,Hainan Medical University,Haikou Hainan,571199,China)

机构地区：[1]中南大学湘雅医学院附属海口医院心脏外科,海南海口570208 [2]海南医学院公共卫生学院环境卫生与职业医学教研室,海南海口571199

出　　处：《职业与健康》2021年第1期103-106,共4页Occupation and Health

基　　金：海南省自然科学基金项目(817130)。

摘　　要：目的系统评价吸烟与阿兹海默症(AD)的相关性。方法计算机检索中国知网(CNKI)、万方(WanFang)、维普中文期刊全文数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、OVID、Elsevier数据库中关于吸烟与AD的病例对照研究和队列研究文献,检索时限均为从建库至2019年12月。纳入文献提取信息,采用RevMan 5.3进行meta分析。结果最终纳入9篇病例对照研究和5篇队列研究。9篇病例对照研究异质性I2=56%,P<0.05,选择随机效应模型分析,OR=0.73,95%CI:0.57~0.94,P<0.05;5篇队列研究异质性I2=86%,P<0.05,选择随机效应模型分析,结果RR=0.88,95%CI:0.62~1.26,P>0.05。结论吸烟暴露可能是阿兹海默症的保护因素,受纳入文献数量和质量影响,上述结论尚待更多高质量研究予以验证。Objective To systematacially evaluate the correlation between smoking and Alzheimer’s disease(AD).Methods PubMed,OVID,Elsevier,VIP,CNKI,WanFang and CBM databases were electronically searched to collect case-control studies and cohort studies on the association of smoking and AD.The time was from the database establishment to December 2019.Extracted data from those studies,then meta-analysis was performed with RevMan 5.3 software.Results A total of 9 case-control studies and 5 cohort studies were included.The heterogeneity of 9 case-control studies was I2=56%,P<0.05,random effect model was selected for analysis.The results were OR=0.73,95%CI:0.57-0.94,P<0.05.The heterogeneity of 5 cohort studies was I2=86%,P<0.05,and the random effect model was selected for analysis.The results were RR=0.88,95%CI:0.62-1.26,P>0.05.Conclusion Suggest that smoking exposure may be a protective factor for AD,but affected by the quantity and quality of the included literature,the above conclusions need to be verified by more high-quality studies.

关 键 词：吸烟 阿兹海默症 META分析 病例对照研究 队列研究 

分 类 号：R181.3[医药卫生—流行病学]