壳聚糖纳米粒子在药物递送系统中的应用进展  

Research progress on application of chitosan nanoparticles in drug delivery system

作　　者：潘超[1] 王晓峰[1] PAN Chao;WANG Xiaofeng(Department of Oral and Maxillofacial Surgery,The Second Hospital Affiliated to Harbin Medical University,Harbin,Heilongjiang,150000)

机构地区：[1]哈尔滨医科大学附属第二医院口腔颌面外科,黑龙江哈尔滨150000

出　　处：《实用临床医药杂志》2021年第4期116-120,共5页Journal of Clinical Medicine in Practice

基　　金：国家自然科学基金项目(81672827)

摘　　要：壳聚糖纳米粒子因其便于修饰、生物相容性好、易于降解、来源广泛等特点,近年来在生物医学领域受到广泛关注。壳聚糖纳米粒子是一种新型载体,相比于传统的纳米载体,其在改善药物稳定性、实现药物控释、提高药物细胞摄取能力等方面具有显著成效。然而,临床应用壳聚糖纳米粒子前,还需预测和评估其潜在毒性与不良反应,明确壳聚糖纳米粒子在体内的吸收、分布、排泄状况及生物相容性、毒性,以确保有效性和安全性。本文综述了壳聚糖纳米粒子在药物递送系统中的应用进展,并对壳聚糖纳米粒子的药物代谢动力学、生物相容性和毒性的研究情况进行简单总结。Chitosan nanoparticles have attracted much attention in biomedical field in recent years because of their easy modification,good biocompatibility,easy degradation and wide sources.Chitosan nanoparticles is a new type of carrier,has significant effect in improving drug stability,achieving drug controlled release and improving drug cell uptake compared with the traditional nano carrier.However,before the clinical application of chitosan nanoparticles,it is necessary to predict and evaluate its potential toxicity and adverse reactions,and clarify the absorption,distribution,excretion,biocompatibility and toxicity of chitosan nanoparticles in vivo,so as to ensure the effectiveness and safety.In this paper,the progress in application of chitosan nanoparticles in drug delivery systems was reviewed,and the research progresses of pharmacokinetics,biocompatibility and toxicity of chitosan nanoparticles were summarized.

关 键 词：壳聚糖纳米粒子 药物递送系统 药物代谢动力学 生物相容性 毒性 

分 类 号：R945[医药卫生—微生物与生化药学] R318[医药卫生—药剂学]