依替膦酸二钠对老年性骨质疏松患者骨密度及骨转换指标的影响  

Effects of Etidronate Disodium on Bone Mineral Density and Bone Turnover Indexes in Elderly Osteoporosis Patients

作　　者：余凯 李华龙 程慎杰[1] 苏建敏[1] Yu Kai;Li Hualong;Cheng Shenjie;Su Jianmin(Department of Orthopaedics,Zhengzhou First People's Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州市第一人民医院骨科,河南郑州450000

出　　处：《哈尔滨医药》2021年第1期18-19,共2页Harbin Medical Journal

摘　　要：目的研究在老年性骨质疏松患者中实行依替膦酸二钠治疗的临床效果以及价值。方法选择160例老年性骨质疏松患者进行随机分组,将行钙尔奇D单独治疗的80例老年性骨质疏松患者作为参照组,将行依替膦酸二钠与钙尔奇D联合治疗的80例老年性骨质疏松患者作为实验组,观察验证参照组以及实验组老年性骨质疏松患者BMD评分、临床有效率。结果实验组老年性骨质疏松患者临床有效率96.25%显著高于参照组临床有效率86.25%,差异具有统计学意义(P<0.0.5)。实验组老年性骨质疏松患者治疗后BMD评分(0.48±0.03)对比参照组数据(0.46±0.02),具有统计学意义(P<0.05)。实验组老年性骨质疏松患者治疗后BMD评分(0.48±0.03)对比治疗前数据(0.46±0.08),具有统计学意义(P<0.0.5)。结论将依替膦酸二钠治疗应用在老年性骨质疏松患者中疗效比较显著,具有临床广泛借鉴的价值。Objective To study clinical effect and value of etidronate disodium(ED)in treatment of elderly osteoporosis patients.Methods A total of 160 elderly osteoporosis patients who were admitted were randomly grouped according to different clinical treatment schemes,80 cases in each group.The patients treated with D-calfor were included in control group,while patients treated with ED and D-calfor were included in experimental group.BMD scores and clinical response rates in both groups were observed and validated.Results The data statistics showed that clinical response rates in experimental group was significantly higher than that in control group(96.25%vs 86.25%)(P<0.05).After treatment,there were significant differences in BMD score between experimental group and control group[(0.48±0.03)points vs(0.46±0.02)points](P<0.05).After treatment,there were significant differences in BMD score in experimental group before and after treatment[(0.46±0.08)vs(0.48±0.03)points](P<0.05).Conclusion The curative effect of ED is significant on elderly osteoporosis patients.

关 键 词：依替膦酸二钠 老年性骨质疏松 骨密度 骨转换指标 

分 类 号：R681.1[医药卫生—骨科学]