基于数据挖掘的含人参-附子药对方剂的组方规律分析  

Analysis on composition rules of Ginseng Radix et Rhizoma-Aconiti Lateralis Radix Praeparata pairs based on data mining method

作　　者：赵萱[1] 陈云慧[2] 郑明月 林薇[4] 郝怡雯 黄玲 范洁溶 赵荷 傅超美[1] ZHAO Xuan;CHEN Yun-hui;ZHENG Ming-yue;LIN Wei;HAO Yi-wen;HUANG Ling;FAN Jie-rong;ZHAO He;FU Chao-mei(School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;College of Basic Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Adelaide Medical School,University of Adelaide,Adelaide 5005,Australia;School of Management,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学药学院,四川成都611137 [2]成都中医药大学基础医学院,四川成都611137 [3]阿德莱德大学医学院,澳大利亚阿德莱德5005 [4]成都中医药大学管理学院,四川成都611137

出　　处：《中草药》2021年第4期1083-1091,共9页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金青年基金项目(81503266);成都中医药大学杏林学者学科人才科研提升项目(QNXZ2019028)。

摘　　要：目的分析含有中医经典药对人参-附子的中医方剂组方规律。方法收集《中医方剂大辞典》中含人参-附子药对的方剂,录入中医传承辅助平台软件(V2.5)建立数据库,分析其主治疾病频次和用药频次,并分析治疗4种高频疾病的方剂组方规律。结果纳入含有人参-附子药对的方剂1067首,高频主治疾病为厥脱、虚劳、脾虚伤食、中风(脑卒中)等14种(频次≥20),常配伍药物21味(频次≥80),核心配伍药物为当归、肉桂、白术、茯苓、甘草、干姜6味,常用药物组合12组。治疗厥脱方剂中,核心配伍药物为白术、茯苓、甘草3味,常用药物组合6种;治疗虚劳方剂中,核心配伍药物为茯苓、肉桂、甘草、牛膝、白术、五味子、干姜、防风8味,常用药物组合52种;治疗中风方剂中,核心配伍药物为茯苓、肉桂、当归、白术、甘草、干姜、防风、麻黄8味,常用药物组合34种,治疗脾虚伤食方剂中,核心配伍药物为茯苓、当归、白术、陈皮、干姜、肉桂、甘草、木香、厚朴9味,常用药物组合25种。结论利用数据挖掘方法探究含人参-附子药对方剂的组方规律,对其临床运用具有一定指导价值,为开展相关药物研发提供依据,也可为药对的组方规律研究提供方法参考。Objective To study the composition rules of traditional Chinese medicine prescription containing classic Chinese medicine pair Renshen(Ginseng Radix et Rhizoma)-Danggui(Aconiti Lateralis Radix Praeparata). Methods The prescriptions containing Ginseng Radix et Rhizoma-Aconiti Lateralis Radix Praeparata pairs in the "Dictionary of Traditional Chinese Medicine Prescriptions" were collected and sorted out, and the database was established by inputting the traditional Chinese medicine inheritance support system(TCMISS)(V2.5) to analyze the rules of prescription formulation for the treatment of four kinds of high-frequency diseases and. Based on the Apriori algorithm of association rules(setting support of 10%, 20%, 30% and confidence of 0.9 respectively), the formula rule of Ginseng Radix et Rhizoma-Aconiti Lateralis Radix Praeparata prescription was analyzed. Selecting four diseases with the highest frequency of treatment, and to analyze the prescription laws of the prescription containing Ginseng Radix et Rhizoma-Aconiti Lateralis Radix Praeparata drugs for treating different diseases. Results Through screening 1067 prescriptions containing "Ginseng Radix et Rhizoma-Aconiti Lateralis Radix Praeparata", and 14 kinds of common diseases were mainly treated in traditional Chinese medicine(frequency ≥20);A total of 236 drugs are involved, including 21 drugs(frequency ≥80) that are often compatible with them, and there are 12 common drug combinations, and six core drugs that are often compatible with them, which include Danggui(Angelicae Sinensis Radix), Rougui(Cinnamomi Cortex), Baizhu(Atractylodis Macrocephalae Rhizoma), Fuling(Poria), etc. There are six kinds of commonly used drug combinations for treating JueTuo, and three kinds of commonly compatible core drugs are Atractylodis Macrocephalae Rhizoma, Poria, Licorice. There are 52 kinds of commonly used drug combinations for treating consumptive disease, and eight kinds of commonly compatible core drugs are Poria, cinnamon, liquorice, Niuxi(Achyranthis bidentatae

关 键 词：人参-附子药对 数据挖掘 组方规律 中医传承辅助平台 中药方剂 

分 类 号：R285[医药卫生—中药学]