蟾皮化学成分和药理活性的研究进展  

Research progress on chemical constituents and pharmacological activities of Bofonis Corium

作　　者：喻昌燕 孟令杰 姜念 李三华 肖毅 刘云 YU Chang-yan;MENG Ling-jie;JIANG Nian;LI San-hua;XIAO Yi;LIU Yun(Guizhou Provincial College-based Key Laboratory for Tumor Prevention and Treatment with Distinctive Medicines,Zunyi Medical University,Zunyi 563000,China;Institute of Life Sciences,Zunyi Medical University,Zunyi 563000,China;Department of Biochemistry and Molecular Biology,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学贵州省普通高等学校特色药物肿瘤防治重点实验室,贵州遵义563000 [2]遵义医科大学生命科学研究院,贵州遵义563000 [3]遵义医科大学生物化学与分子生物学教研室,贵州遵义563000

出　　处：《中草药》2021年第4期1206-1220,共15页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81660611);贵州省科技计划项目(黔科合支撑[2020]4Y154);遵义市科技计划项目(遵市科合社字[2018]18号,遵市科合HZ字[2020]83号);遵义医科大学科研启动资金项目(F-843)。

摘　　要：蟾皮为蟾蜍科动物中华大蟾蜍Bufo bufo gargarizans或黑眶蟾蜍B.melanosticus的干燥全皮,已纳入壮药名录。作为一种民族药,常用于满族、回族和朝鲜族的民间药方,具有清热解毒和利水消肿之功效。目前已从蟾皮中发现100多个化合物,包括蟾蜍二烯羟酸内酯类、吲哚生物碱类、蟾蜍环酰胺类以及甾体类等成分。随着国内外药理学研究的不断深入,蟾皮单体成分呈现诸多药理作用,如抗肿瘤、抗炎、免疫调节、抗乙肝病毒、强心等,并且对特异的药物代谢酶具有较高的敏感性。通过查阅近20年来的国内外文献,对蟾皮的化学成分、药理活性、单体成分与药物代谢酶的相互作用等方面进行综述,以期为蟾皮更好的开发和应用提供参考。Bofonis Corium is the dry skin of Bufo bufo gargarizans or B. melanosticus, which has been included in the list of Zhuang medicine. As an ethnic medicine, it is often used in the folk prescriptions of Manchu, Hui and Korean nationalities, which has the effect of clearing heat and detoxification and reducing swelling. At present, more than 100 compounds have been found, including bufadienolides, indole alkaloids, bufogargarizanines, and steroids. With the development of pharmacology, the chemical constituents of Bofonis Corium have shown many pharmacological effects, such as anti-tumor, anti-inflammatory, immune regulation, anti-hepatitis B virus, heart strengthening, etc., which are also highly sensitive to specific drug metabolizing enzymes. In this paper, the chemical constituents, pharmacological activities, and interaction between monomer components and drug metabolizing enzymes of Bofonis Corium in recent 20 years are reviewed in order to provide a reference for the further development and rational utilization of Bofonis Corium.

关 键 词：中华大蟾蜍 黑眶蟾蜍 民族药 蟾皮 蟾蜍二烯羟酸内酯类 抗肿瘤 免疫调节 药物代谢酶 

分 类 号：R282.71[医药卫生—中药学]