某二甲医院铜绿假单胞菌标本来源、病区分布及耐药性分析  

Distribution and drug resistance of pseudomonas aeruginosa in a county hospital

作　　者：卢斌[1] 姚燕[1] 陆英[1] 樊国芳[2] 余小春[3] 王谦信[4] LU Bin;YAO Yan;LU Ying;FAN Guofang;YU Xiaochun;WANG Qianxin(Clinical Laboratory,People's Hospital of Changshan County,Changshan 324200,China)

机构地区：[1]常山县人民医院检验科,324200 [2]常山县人民医院全科医学科,324200 [3]常山县人民医院院感科,324200 [4]常山县人民医院感染科,324200

出　　处：《浙江医学》2021年第6期653-655,共3页Zhejiang Medical Journal

基　　金：衢州市指导性科技计划项目(2015119)。

摘　　要：目的分析某二甲医院铜绿假单胞菌标本来源、病区分布及耐药性,为防控医院感染及合理使用抗菌药物提供依据。方法对2016年1月1日至2018年12月31日常山县人民医院住院病区送检的各类标本中培养分离获得的1981株铜绿假单胞菌株进行标本来源、病区分布分析;同时采用纸片扩散法进行药敏试验,分析其耐药性。结果铜绿假单胞菌主要来源于痰液(57.04%)、尿液(17.47%)等标本;病区分布以重症医学科(56.34%)、呼吸内科(9.49%)、外二科(5.25%)、外一科(5.05%)为主。铜绿假单胞菌对氨苄西林、头孢唑啉、头孢曲松、头孢替坦、氨苄西林/舒巴坦、复方新诺明、呋喃妥因的耐药率均>95%;对环丙沙星、哌拉西林/他唑巴坦、头孢吡肟的耐药率均<10%,对(阿米卡星、妥布霉素、庆大霉素、左氧氟沙星)的耐药率均<5%,对氨曲南、厄他培南未见耐药。结论铜绿假单胞菌对部分抗菌药物已产生较高的耐药性,应重视医院感染控制,合理应用抗菌药物。Objective To analyse the distribution and drug resistance of pseudomonas aeruginosa isolates in a county hospital,and to provide an objective basis for hospital infection prevention and control,and rational use of antibacterial drugs.Methods A total of 1981 clinical strains of pseudomonas aeruginosa were collected from Changshan County People's Hospital during Jan 1,2016 to Dec 31,2018.The distribution of bacteria was analyzed and drug resistance was tested by kirby-bauer method.Results The strains of pseudomonas aeruginosa were mainly isolated from sputum(57.04%)and urine(17.47%)specimens,which were collected from intensive care unit(56.34%),respiratory department(9.49%),second surgical department(5.25%)and first surgical department(5.05%).Pseudomonas aeruginosa had a resistance rate of more than 95% to ampicillin,cefazolin,ampicillin/sulbactam,ceftriaxone,cefotetan,co-trimoxazole,nitrofurantoin,etc.However,the drug resistance rates to tazobactam and cefepime were all<10%,and the resistance rates to tobramycin,gentamicin and levofloxacin were less than 5%.No resistant strains were found for aztreonam and ertapenem.Conclusion Pseudomonas aeruginosa has developed high resistance to some antibiotics.Attention should be paid to nosocomial infection control and rational use of antibiotics.

关 键 词：铜绿假单胞菌 抗菌药物 耐药性 

分 类 号：R446.5[医药卫生—诊断学]