钙离子信号及细胞调控信号网络动力学  

Dynamics of calcium signals and the intracellular regulatory signaling network

作　　者：李翔 祁宏 黄艳东 帅建伟 LI Xiang;QI Hong;HUANG YanDong;SHUAI JianWei(Fujian Provincial Key Lab for Soft Functional Materials Research,Research Institute for Biomimetics ami Soft Matter,Department of Physics,College of Physical Science and Technology,Xiamen University,Xiamen 361005,China;Complex Systems Research Center,Shanxi University,Taiyuan 030006,China;College of Computer Engineering,Jimei University,Xiamen 361021,China)

机构地区：[1]厦门大学物理科学与技术学院物理学系,生物仿生与软物质研究院,福建省柔性功能材料重点实验室,厦门361005 [2]山西大学复杂系统研究所,太原030006 [3]集美大学计算机工程学院,厦门361021

出　　处：《中国科学：物理学、力学、天文学》2021年第3期99-111,共13页Scientia Sinica Physica,Mechanica & Astronomica

基　　金：国家自然科学基金(编号:11675134,11704318,11874310)资助项目。

摘　　要：钙离子(Ca^(2+))是细胞内广泛存在的一种重要的第二信使,参与并控制着几乎所有的生命活动过程.细胞信号分子网络对细胞正常和病理生理活动过程进行着精密调控,确保细胞各项生理功能有序地进行.本文综述了近些年本课题组关于细胞内钙信号及细胞信号网络动力学模型方面的研究进展,包括集团化钙离子通道释放局域钙信号、细胞全局钙波信号、内质网和线粒体钙微域调控钙信号和钙信号调控细胞凋亡信号网络动力学,以及细胞信号调控网络动力学等.这些理论工作为研究钙信号和蛋白质信号网络调控细胞复杂生命过程的动力学机制提供了方向和思路.The calcium ion(Ca^(2+))acts as a ubiquitous cellular messenger,regulating a wide variety of cellular processes.The intracellular signaling network precisely controls the normal and pathophysiological functions of cells to conduct various physiological activities.This article reviews our research progress on the dynamics of intracellular Ca^(2+)signaling and cellular signaling network models in recent years,including the release of local Ca2+signals from clustered Ca^(2+)channels,global Ca2+waves in cells,Ca2+regulation with microdomains between the endoplasmic reticulum and mitochondria,dynamics of cell apoptosis regulated by Ca2+signaling,and dynamics of cellular signaling regulation networks.These simulation studies provide directions and ideas for future research on how Ca^(2+)signals and cellular signaling networks regulate the complicated life functions in cells.

关 键 词：钙信号 内质网 IP3R离子通道 细胞死亡 信号网络动力学 

分 类 号：Q25[生物学—细胞生物学]