抗菌型胆道支架的研究进展  

Research Progress of Antibacterial Biliary Stent

作　　者：刘文静 李超婧 戚晓升[3] 王程毅 关国平[1,2] 王富军[1,2,4] 王璐[1,2,5] LIU Wenjing;LI Chaojing;QI Xiaosheng;WANG Chengyi;GUAN Guoping;WANG Fujun;WANG Lu(College of Textiles,Donghua University,Shanghai,201620;Key Laboratory of Textile Science&Technology,Ministry of Education,Shanghai,201620;The First People's Hospital Affiliated to Shanghai Jiao Tong University,Shanghai,201620;Engineering Research Center of Industrial Textiles of Donghua University,Shanghai,201620;Donghua University Key Laboratory of Biomedical Textile Materials and Technology in Textile Industry,Shanghai,201620)

机构地区：[1]东华大学纺织学院,上海市201620 [2]东华大学纺织面料技术教育部重点实验室,上海市201620 [3]上海交通大学附属第一人民医院,上海市201620 [4]东华大学产业用纺织品教育部工程研究中心,上海市201620 [5]东华大学纺织行业生物医用纺织材料与技术重点实验室,上海市201620

出　　处：《中国医疗器械杂志》2021年第2期183-187,204,共6页Chinese Journal of Medical Instrumentation

摘　　要：胆道支架已普遍应用于胆道狭窄和胆道梗阻的治疗并能有效缓解患者痛苦,但术后细菌感染及支架堵塞依旧是一大难题。介绍胆道支架植入后由细菌入侵引发的感染和支架堵塞机制,阐述细菌生物膜和胆汁污泥的形成机理。抗菌型胆道支架是抑制胆道感染的有效途径,综述国内外采用不同抗菌方式对胆道支架抗菌改性的相关文献,总结并展望抗菌型胆道支架的研究前景。Biliary stent has been widely used in the treatment of biliary stricture and obstruction,it can relieve the pain of patients effectively,but bacterial infection and stent obstruction are still troublesome after surgery.We introduce the mechanism of infection and stent blockage caused by bacterial invasion after biliary stent implantation,and expound the formation mechanism of bacterial biofilm and bile sludge in this review.Antibacterial biliary stent is an effective way to inhibit biliary tract infection,the literatures on antibacterial modification of biliary stent with different antibacterial methods in domestic and abroad are reviewed,and the research prospect of antibacterial biliary stent is summarized and prospected.

关 键 词：胆道支架 生物膜 胆泥 抗菌 抗粘附 

分 类 号：R197.39[医药卫生—卫生事业管理]