抗菌药物与洛匹那韦/利托那韦相互作用研究进展  

Research Progress of Interactions Between Antibacterials and Lopinavir/Ritonavir

作　　者：张若英 徐颖颖[1] 郑韧 王怀冲[1] 王宇[1] 蔡鑫君[1] ZHANG Ruoying;XU Yingying;ZHENG Ren;WANG Huaichong;WANG Yu;CAI Xinjun(Department of Pharmacy,Zhejiang Integrated Traditional and Western Medicine Hospital,Hangzhou 310003,China)

机构地区：[1]浙江省中西医结合医院药学部,杭州310003

出　　处：《中国现代应用药学》2021年第4期503-507,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省药学会医院药学专项科研资助项目(2019ZYY27);杭州市医坛新秀培养对象(2020年度)。

摘　　要：口服抗病毒药洛匹那韦/利托那韦的抗病毒作用受很多因素的影响,如患者性别、种族、合并症、用药依从性等。与其他药物的相互作用也是影响洛匹那韦/利托那韦抗病毒的重要因素之一,其中一些抗菌药物对洛匹那韦/利托那韦的影响较大且机制复杂,作用持续时间也较长,对于联用洛匹那韦/利托那韦合并细菌或真菌感染的患者,抗菌药物的选择与监测更为重要。本文通过综述国内外相关研究,探讨和总结洛匹那韦/利托那韦与抗菌药物的相互作用机制和应对策略,比较不同抗菌药物的药动学特性及与洛匹那韦/利托那韦相互作用的差异,从而为抗菌药物的选择和相应剂量的调整提供参考,降低患者用药风险,提高安全性。The effectiveness of lopinavir/ritonavir,an oral antiviral drug,was affected by patient’s sex,race,presence of comorbidities,adherence.Interactions with other drugs was also one of the important factors affecting the antiviral action of lopinavir/ritonavir,the interactions among lopinavir/ritonavir and some antibacterials were major,complex and delayed.Thus,the choice of antibacterials and concentration monitoring were very important for the patient with bacterial or fungal infections receiving lopinavir/ritonavir treatment.This review summarized the data about the influence of antibacterials on lopinavir/ritonavir treatment and analyzed interaction mechanisms and suggested management to provide reference about choice of antibacterials and dosage adjustment of antibacterials,to avoid the risk of medication and improved safety.

关 键 词：抗菌药物 洛匹那韦/利托那韦 相互作用 

分 类 号：R969.2[医药卫生—药理学]