二甲双胍联合达英-35对多囊卵巢综合征患者氧化应激及卵巢功能的影响  

Effects of metformin combined with Diane-35 on oxidative stress and ovarian function in patients with polycystic ovarian syndrome

作　　者：王雪丽 Wang Xue-li(Department of Obstetrics and Gynecology,Yuzhou Maternal and Child Health Hospital,Xuchang 46167,Henan,China)

机构地区：[1]禹州市妇幼保健院妇产科,河南许昌461670

出　　处：《四川生理科学杂志》2021年第2期260-262,249,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨二甲双胍联合达英-35对多囊卵巢综合征患者氧化应激水平及卵巢功能的影响。方法:选取我院2018年4月至2019年4月收治的90例多囊卵巢综合征患者,根据盲抽法分为2组(n=45)。对照组患者口服达英-352 mg Qd进行治疗,观察组在此基础上口服二甲双胍片500 mg Tid进行治疗。治疗3 m后观察临床疗效,采用酶联免疫吸附法测定血清卵泡刺激素(Follicle-stimulating hormone,FSH)、促黄体生成素(Luteinizing hormone,LH)、胰岛素(Insulin,INS)、睾酮(Testosterone,T)、雌二醇(Estradiol,E2)及超氧化物歧化酶(Superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(Glutathione peroxidase,GPx)、总抗氧化能力(Total antioxidant capacity,TAC)水平,并经B超检查观察囊性卵泡数、卵泡直径、卵泡成熟期子宫内膜厚度。结果:治疗后,观察组总有效率明显高于对照组(95.56%vs 80.00%,P<0.05);治疗后,两组患者FSH、LH、INS、T、E2水平均较治疗前明显降低(P<0.05),SOD、GPx、TAC水平均较治疗前明显升高(P<0.05),且观察组均优于对照组(P<0.05);治疗后,两组患者囊性卵泡数明显减少、卵泡直径明显增大,卵泡成熟期子宫内膜厚度厚于治疗前,且观察组上述指标变化幅度均高于对照组(P<0.05)。结论:二甲双胍联合达英-35对多囊卵巢综合征疗效显著,能够减轻机体氧化应激,改善卵巢情况及生理功能,值得推广应用。Objective:To investigate the effect of metformin combined with Diane-35 on oxidative stress and ovarian function in patients with polycystic ovarian syndrome.Methods:A total of 90 patients with polycystic ovarian syndrome who were received by the hospital from April 2018 to April 2019 were divided into two groups according to blind selection method(n=45).The patients in the control group were treated with daying-352 mg Qd orally,and the patients in the observation group were treated with metformin tablets 500 mg Tid orally on the basis of the control group.After 3 m of treatment,the clinical efficacy was compared,and the enzyme-linked immunosorbent assay(ELISA)method was used to determine the levels of serum follicle-stimulating hormone(FSH),luteinizing hormone(LH),Insulin(INS),testosterone(T),estradiol(E2)and oxidative stress levels including Superoxide Dismutase(SOD),Glutathione peroxidase(GPx),total antioxidant capacity(TAC),and number of cystic follicles,follicle diameter,endometrial thickness of follicular maturity were measured by B-ultrasound.Results:After treatment,the total effective rate of observation group was higher than that of control group(95.56%vs 80.00%,P<0.05).There was no statistical difference in the levels of FSH,LH,INS,T,E2,SOD,GPx and TAC between two groups before treatment(P>0.05).After treatment,the levels of FSH,LH,INS,T and E2 in two groups were lower than those before treatment,the levels of SOD,GPx and TAC were higher than those before treatment,and observation group was better than control group(P<0.05).Conclusion:Metformin combined with Diane-35 in treatment of polycystic ovarian syndrome is effective,it can reduce oxidative stress and improve ovarian function,which is worthy of promotion and application.

关 键 词：多囊卵巢综合征 二甲双胍 达英-35 氧化应激 卵巢功能 B超检查结果 

分 类 号：R71[医药卫生—妇产科学]