甲状腺未分化癌靶向治疗研究进展  

Advance in Targeted Therapy for Anaplastic Thyroid Carcinoma

作　　者：蔡云真 骆传鸿 曾祥泰[1] CAI Yun-zhen;LUO Chuan-hong;ZENG Xiang-tai(Department of Thyroid Surgery,the First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China)

机构地区：[1]赣南医学院第一附属医院甲状腺外科,江西赣州341000

出　　处：《实用临床医学（江西）》2021年第1期101-106,共6页Practical Clinical Medicine

摘　　要：甲状腺未分化癌是一种非常罕见的甲状腺肿瘤,因肿瘤细胞分化差、高度侵袭性,成为甲状腺癌的主要死亡原因。虽传统手术或者放化疗等治疗方法在甲状腺分化癌方面取得令人鼓舞的效果,但其对未分化癌的治疗效果不明显。靶向治疗是近年来发展较为迅速的一种针对晚期肿瘤的治疗方法,机制是通过药物特异性结合或阻断已明确的致癌位点,在细胞分子水平层面杀伤肿瘤细胞而不损伤正常细胞。随着靶向治疗临床试验研究的深入,发现靶向治疗对提高甲状腺未分化癌病人总生存期(overall survival,OS)方面有明显的效果,逐渐成为治疗甲状腺未分化癌的研究热点之一。文章结合近些年来靶向药物在甲状腺未分化癌治疗方面的研究,综述甲状腺未分化癌的靶向治疗进展。Anaplastic thyroid carcinoma is a rare thyroid tumor,which is the main cause of death due to poorly differentiated and highly invasive tumor cells.Although traditional surgery or chemoradiotherapy has yielded encouraging results in anaplastic thyroid cancer,there is still no solution for anplastic thyroid carcinoma.Targeted therapy is a rapidly developed treatment method for advanced tumors in recent years.The mechanism of targeted therapy is to kill tumor cells at the cellular and molecular levels without damaging normal cells through specifically binding to or blocking the identified oncogenic sites with drugs.With the deepening of clinical trials of targeted therapy,it has been found that targeted therapy has an obvious effect on improving the overall survival of patients with anaplastic thyroid carcinoma.Therefore,it has gradually become one of the research hotspots in the treatment of anaplastic thyroid cancer.In this paper,the progress of targeted therapy in anaplastic thyroid carcinoma is reviewed based on the recent studies on targeted drugs for anaplastic thyroid cancer.

关 键 词：甲状腺未分化癌 信号通路 靶向治疗 

分 类 号：R320[医药卫生—人体解剖和组织胚胎学]