侵袭性肺部真菌感染的实验室检测方法  

Laboratory detection methods of invasive pulmonary fungal infection

作　　者：郭鹏豪[1] 廖康[1] 伍众文[1] 何宇婷[1] 陈怡丽[1] 刘敏[1] GUO Peng-hao;LIAO Kang;WU Zhong-wen(Department of Clinical Laboratory, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China)

机构地区：[1]中山大学附属第一医院医学检验科,广州510080

出　　处：《中国临床新医学》2021年第3期225-230,共6页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：中山大学校级本科教学质量工程类建设项目(编号:80000-18832601)。

摘　　要：近年来,侵袭性肺部真菌感染的发病率逐年上升,并逐渐成为导致患者死亡的重要原因之一。由于侵袭性肺部真菌感染临床表现缺乏特异性,早期诊断困难,且病情易被基础病掩盖,造成误诊﹑漏诊而延误治疗。精准的实验室诊断是实现精准临床诊疗的前提和基础。该文对目前侵袭性肺部真菌感染常用实验室检测方法,包括标本直接镜检、组织病理学检查、真菌培养、抗原检测、核酸检测等的诊断性能及注意事项进行介绍与评价,从而提高临床医师及实验室人员对侵袭性肺部真菌感染实验室检测方法的认识。In recent years,the incidence rate of invasive pulmonary fungal infection(IPFI)has increased year by year,and has gradually become one of the important causes of death in the patients.Due to the lack of specificity of clinical manifestations of IPFI,early diagnosis is difficult,and the disease is easy to be masked by the underlying disease,resulting in misdiagnosis,missed diagnosis and delayed treatment.Accurate laboratory diagnosis is the premise and foundation of accurate clinical diagnosis and treatment.In this paper,we introduce and evaluate the diagnostic performance and precautions of commonly used laboratory detection methods for IPFI at present,including direct microscopic examination of specimens,histopathological examination,fungal culture,antigen detection and nucleic acid detection,so as to improve the understanding of clinicians and laboratory staff on the laboratory detection methods for IPFI.

关 键 词：侵袭性肺部真菌感染 实验室 检测方法 

分 类 号：R446[医药卫生—诊断学]