大型真菌来源鸟巢烷型二萜研究进展  

Research Progress on Cyathanes from Macrofungi

作　　者：彭勤颖 邹根 高利慧 白林泉[2] TAN Yeeshin 吴莹莹[1,2] PENG Qinying;ZOU Gen;GAO Lihui;BAI Linquan;TAN Yeeshin;WU Yingying(Institute of Edible Fungi,Shanghai Academy of Agricultural Sciences,National Engineering Research Center of Edible Fungi,Key Laboratory of Applied Mycological Resources and Utilization(South),Ministry of Agriculture and Rural Affairs,P.R.China,Shanghai 201403,China;State Key Laboratory of Microbial Metabolism,School of Life Sciences&Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China;Institute of Biological Sciences,Faculty of Science&Mushroom Research Centre,University Malaya,Kuala Lumpur 50603,Malaysia)

机构地区：[1]上海市农业科学院食用菌研究所,国家食用菌工程技术研究中心,农业农村部南方食用菌资源利用重点实验室,上海201403 [2]上海交通大学生命科学技术学院,微生物代谢国家重点实验室,上海200240 [3]马来亚大学生物科学研究所,马来亚大学理学院&菌类研究中心,吉隆坡50603

出　　处：《食用菌学报》2021年第2期140-154,共15页Acta Edulis Fungi

基　　金：上海市闵行区“领军人才”培养计划(201947);上海市科委国际科技合作基金项目(18390741000)。

摘　　要：鸟巢烷型二萜是大型真菌来源二萜化合物中最大的类群,其化学结构特征是包含5/6/7元环杂合的三环骨架。由于鸟巢烷型二萜具有以刺激神经生长因子合成为代表的多种生物活性,其人工合成和相关药物开发引起了广泛关注。总结近年来报道的来源于黑蛋巢菌属(Cyathus)、猴头菌属(Hericium)和肉齿菌属(Sarcodon)等大型真菌的多种鸟巢烷型二萜的化学结构和生物活性,介绍其化学合成和生物合成方面的研究进展。Cyathanes with 5/6/7 ring-fused diterpenes are the largest group of diterpenoids from macrofungi.Due to their rich biological activities,especially the nerve growth factor-inducing activity,cyathanes have attracted considerable attentions in terms of drug discovery and compound synthesis.This review compiled research progress on chemical structure and biological activity of cyathanes from Cyathus,Hericium and Sarcodon.Progress on both chemical synthesis and biosynthesis of cyathanes were also reviewed so as to provide a reference for research and development of natural products from macrofungi in the future.

关 键 词：鸟巢菌 化学结构 生物活性 化学合成 生物合成 二萜环化酶 

分 类 号：Q936[生物学—微生物学]