医用高分子材料抗凝血表面构建策略及研究进展  

Construction Strategy and Research Progress of Anticoagulant Surface of Medical Polymeric Materials

作　　者：栾轲 班雨 施德安 石恒冲[2] LUAN Ke;BAN Yu;SHI Dean;SHI Hengchong(Hubei Key Laboratory of Polymer Materials,School of Materials Science and Engineering,Hubei University,Wuhan 430062,China;State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China)

机构地区：[1]湖北大学材料科学与工程学院,高分子材料湖北省重点实验室,武汉430062 [2]中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,长春130022

出　　处：《功能高分子学报》2021年第2期172-181,共10页Journal of Functional Polymers

基　　金：国家自然科学基金面上项目(51973221);山东省重大科技创新工程项目(2019JZZY011105);国家重点研发计划(2020YFC1106900);工信部生物医用材料平台项目(TC190H3ZV/1)。

摘　　要：医用高分子材料及医疗器械主要用于疾病的诊断和治疗。此种材料/器械在植/介入人体与血液接触时,血浆蛋白会在几秒钟内吸附到材料/器械表面,并与血小板上的糖蛋白受体结合,导致血小板活化、凝血级联以及补体激活,形成凝血及血栓,严重危及病人的健康及生命安全。为了赋予材料/器械表面抗凝血性能,需有针对性地进行抗凝血表面构建,其方法主要为:生物惰性涂层、生物活性涂层、具有内皮(EC)特异性生长因子的表面涂层和复合抗凝涂层。本文结合国内外该领域研究动态及本课题组近年来在医用高分子材料及医疗器械抗凝血表面构建的研究成果,概述了抗凝血表面构建及其在医疗器械中应用的研究进展。Biomedical polymer materials and medical devices are mainly used for the diagnosis and treatment of diseases,and are used by thousands of patients every day.When this material/device is implanted/intervened in the human body and comes into contact with blood,plasma proteins will adsorb to the surface of the material/device within a few seconds and bind to the glycoprotein receptor on the platelet,resulting in platelet activation,coagulation cascade and complement activation,coagulation and thrombus.Human health and life safety are seriously endangered.To impart anticoagulant properties to the surface of materials/devices,it is necessary to construct anticoagulant surfaces in a targeted manner.The main methods are as follows:biologically inert coatings,biologically active coatings,surface coatings with endothelial(EC)specific growth factors,and composite anti-coagulation coating.Based on the research developments in this field at home and abroad and the research results of our group in recent years in the construction of anticoagulant surface of biomedical polymer material and medical device,this review summarizes the research progress of anticoagulant surface construction and its application in medical devices.

关 键 词：生物医用高分子材料 医疗器械 抗凝血 生物相容性 

分 类 号：O63[理学—高分子化学]