尿神经生长因子作为诊断膀胱过度活动症的生物标志物的Meta分析  

Urinary nerve growth factor used as a biomarker for overactive bladder:a Meta - analysis

作　　者：熊志 任杰[1] 郝晓杰 高宏飞[2] XIONG Zhi;REN Jie;HAO Xiaojie;GAO Hongfei(Shanxi Medical University,Taiyuan 030001;Department of Urology,First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学,山西太原030001 [2]山西医科大学第一医院泌尿外科,山西太原030001

出　　处：《现代泌尿外科杂志》2021年第3期209-215,共7页Journal of Modern Urology

基　　金：山西省留学回国人员科技活动择优资助项目(No.晋人社厅函[2017]397)。

摘　　要：目的 系统评价尿神经生长因子(NGF)与膀胱过度活动症(OAB)之间的关系。方法 从PubMed、Web of Science、Embase、CNKI及Cochrane Library数据库中检索建库至2019年12月所有关于尿NGF与OAB关系的文献资料,由2名研究者独立进行文献筛选、数据提取及文献质量评价,使用Review Manager Version 5.3软件进行Meta分析。结果 共纳入25篇文献。分析结果显示OAB患者尿NGF(SMD=0.98,95%CI:1.42~2.75,P<0.000 01)水平和尿NGF/尿肌酐(Cr)(SMD=1.13,95%CI:0.72~1.55,P<0.000 01)均明显高于对照组,OAB患者经治疗后尿NGF水平(SMD=1.26,95%CI:0.61~1.90,P=0.000 1)和尿NGF/Cr(SMD=1.18,95%CI:0.59~1.78,P=0.000 1)明显下降。OAB伴尿失禁患者尿NGF(SMD=0.66,95%CI:0.47~0.85,P<0.000 01)和NGF/Cr(SMD=0.49,95%CI:0.34~0.63,P<0.000 01)水平明显高于OAB不伴尿失禁者患者。但间质性膀胱炎/膀胱疼痛综合征(IC/PBS)患者与OAB患者尿NGF/Cr(SMD=0.17,95%CI:-0.06~0.40,P=0.16)水平无显著性差异。结论 本Meta分析表明,尿NGF水平与NGF/Cr可能是诊断OAB的潜在生物标志物,是区分OAB伴或不伴急迫性尿失禁的潜在生物标志物,也是能够用于评估OAB治疗效果的潜在生物标志物。Objective To explore the association between urinary nerve growth factor(NGF)and overactive bladder(OAB).Methods Studies on the relationship between urinary NGF and OAB were searched in PubMed,Web of Science,Embase,CNKI and Cochrane Library from inception to Dec.2019.Studies selection,data extraction and quality evaluation were conducted by two researchers independently.Meta-analysis was conducted with Review Manager Version 5.3 software.Results A total of 25 published studies were included.Analysis showed that the levels of NGF(SMD=0.98,95%CI:1.42-2.75,P<0.00001)and NGF/Cr(SMD=1.13,95%CI:0.72-1.55,P<0.00001)were significantly higher in OAB patients than in controls.After treatment,the levels of NGF(SMD=1.26,95%CI:0.61-1.90,P=0.0001)and NGF/Cr(SMD=1.18,95%CI:0.59-1.78,P=0.0001)significantly decreased.The levels of NGF and NGF/Cr were much higher in OAB patients with urinary incontinence(SMD=0.66,95%CI:0.47-0.85,P<0.00001)than in OAB patients without urinary incontinence(SMD=0.49,95%CI:0.34-0.63,P<0.00001).There was no significant difference in NGF/Cr(SMD=0.17,95%CI:-0.06-0.40,P=0.16)between patients with interstitial cystitis/painful bladder syndrome(IC/PBS)and patients with OAB.Conclusion Urinary NGF and NGF/Cr levels may be potential indicators to diagnose OAB,to differentiate OAB with and without urinary incontinence,and to evaluate the treatment efficacy.

关 键 词：尿神经生长因子 膀胱过度活动症 生物标志物 META分析 

分 类 号：R694.5[医药卫生—泌尿科学]