男性不育症患者抗米勒管激素水平与性激素、精液参数水平的相关性分析  

Correlation of anti-Müllerian hormone with sex hormone and semen parameters in male infertility

作　　者：郑建波 陈辉[1] 郑其梅 于芳 史建华 董强 王冬梅[1] ZHENG Jianbo;CHEN Hui;ZHENG Qimei;YU Fang;SHI Jianhua;DONG Qiang;WANG Dongmei(Reproductive Center,Yantaishan Hospital,Yantai 264008,Shandong,China;Department of Obstetrics and Gynecology,Anqiu People′s Hospital,Weifang 262100,Shandong,China)

机构地区：[1]烟台市烟台山医院生殖中心,山东烟台264008 [2]安丘市人民医院妇产科,山东潍坊262100

出　　处：《中国性科学》2021年第1期7-9,共3页Chinese Journal of Human Sexuality

基　　金：烟台市重点研发计划资助(2017YD018)。

摘　　要：目的分析男性不育症患者血清及精浆抗米勒管激素(AMH)水平与性激素及精液参数水平的相关性,评估AMH对男性不育症的诊断价值。方法选取2017年3月至2019年3月烟台市烟台山医院生殖中心诊治的132例男性不育症患者作为研究对象。阴囊彩超下计算双侧睾丸体积,进行精液参数、精浆和血清AMH水平及性激素水平检测。结果血清AMH水平与精浆AMH水平无线性相关性(P>0.05),精浆AMH水平显著高于血清AMH水平,差异具有统计学意义(P<0.01)。精浆AMH水平与睾丸体积(R^(2)=0.192,P<0.05)、精子浓度(R^(2)=0.296,P<0.01)、前向运动精子百分率(R^(2)=0.365,P<0.01)呈正相关,与促卵泡激素(FSH)(R^(2)=-0.264,P<0.01)、黄体生成素(LH)(R^(2)=-0.321,P<0.01)呈负相关,与年龄、精液量、睾酮(T)、催乳素(PRL)及雌二醇(E 2)无相关性(P>0.05);而血清AMH水平与年龄、睾丸体积、精液参数水平及性激素参数水平均无相关性(P>0.05)。结论精浆AMH浓度与精子浓度、精子活力显著相关,睾丸内AMH可能与精子的发生有关,而血清AMH对男性不育症的生育力评估意义不大。Objective To evaluate the diagnostic value of anti-Müllerian hormone(AMH)in male infertility by analyzing the correlation between serum and seminal plasma levels of AMH and sex hormone and semen parameters.Methods A total of 132 male infertility patients diagnosed and treated in the Reproductive Center of Yantaishan Hospital from March 2017 to March 2019 were selected as the research subjects.Bilateral testicular volume was calculated under scrotal ultrasonography.Semen parameters,semen,serum AMH levels and sex hormone levels were detected.Results There was no linear correlation between serum AMH level and seminal plasma AMH level(P>0.05),and the seminal plasma AMH level was significantly higher than that of serum AMH level,with statistical significance(P<0.01).Seminal plasma AMH level were positively correlated testicular volume(R^(2)=0.192,P<0.05),sperm concentration(R^(2)=0.296,P<0.01),the forward movement of sperm percentage(R^(2)=0.365,P<0.01),and showed a negative correlation with follicle stimulating hormone(FSH)(R^(2)=0.264,P<0.01),luteinizing hormone(LH)(R^(2)=0.321,P<0.01),and have no relation with age,semen volume,testosterone(T),prolactin(PRL),estradiol(E 2)(P>0.05).The serum AMH level has no significant correlation with age,testicular volume,semen parameters and sex hormone parameters(P>0.05).Conclusions The concentration of AMH in seminal plasma is significantly correlated with sperm concentration and sperm motility,and AMH in testis may be related to spermatogenesis,while serum AMH has little significance in the fertility assessment of male infertility.

关 键 词：抗米勒管激素 男性不育 精液参数 性激素 

分 类 号：R697[医药卫生—泌尿科学]