补中益气汤加味辅助电刺激生物反馈治疗气虚型盆底功能障碍性疾病的疗效分析  

Efficacy of electrical stimulation biofeedback assisted with Buzhong Yiqi Decoction in the treatment of pelvic floor dysfunction with qi-deficiency

作　　者：张丽玲[1] 张贵清[1] 肖琳[1] 王宇[1] 徐秀英[1] 陈丽融 ZHANG Liling;ZHANG Guiqing;XIAO Lin;WANG Yu;XU Xiuying;CHEN Lirong(Department of Obstetrics,Dazhou Integrated TCM Western Medicine Hospital,Dazhou 635001,Sichuan,China)

机构地区：[1]达州市中西医结合医院妇产科,四川达州635001

出　　处：《中国性科学》2021年第1期102-105,共4页Chinese Journal of Human Sexuality

基　　金：四川省达州市2019卫健委医学科研科技计划项目(2019025)。

摘　　要：目的探讨补中益气汤加味辅助电刺激生物反馈治疗气虚型盆底功能障碍(PFD)性疾病的疗效和对其生活质量的影响。方法选取2017年2月至2018年8月达州市中西医结合医院治疗的256例气虚型PFD患者的临床资料作为研究对象,进行回顾性分析。根据治疗方案将患者分为研究组(n=131)和对照组(n=125)。对照组入院后均给予电刺激生物反馈治疗及凯格尔运动治疗法,研究组在对照组基础上加用补中益气汤辩证加减。对两组进行6个月的随访,比较两组疗效、盆底肌情况、生活质量、症状相关评分及阴道内细胞因子相关水平的差异,并采用多因素Logistic回归模型分析影响患者生活质量的相关因素。结果研究组治疗后与末次随访时治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05);研究组治疗后及末次随访时UDI-7、PFDI-20及PFIQ-7评分较对照组均显著较低,差异具有统计学意义(P<0.05);研究组末次随访时TGF-β1及TIMP-2较对照组显著升高,MMP-2较对照组显著下降,差异具有统计学意义(P<0.05);多因素Logistic回归分析结果显示,1次分娩史是导致患者治疗后生活质量无显著改善的危险因素,而中药辅助治疗是保护因素。结论补中益气汤辅助电刺激生物反馈疗法治疗气虚型PFD患者,可以有效改善患者盆底功能,提升疗效,改善患者生活质量。Objective To investigate the efficacy of electrical stimulation biofeedback assisted with Buzhong Yiqi Decoction in the treatment of pelvic floor dysfunction(PFD)with qi deficiency and its effect on quality of life.Methods Clinical data of 256 patients with qi-deficiency PFD treated in Dazhou Integrated TCM Western Medicine Hospital from February 2017 to August 2018 were retrospectively analyzed as the research subjects.Patients were divided into study group(n=131)and control group(n=125)according to treatment regimens.The control group was given electrical stimulation biofeedback therapy and Kegel exercise therapy after admission,and the research group was combined with Buzhong Yiqi Decoction dialectically.After 6 months follow-up,the efficacy,pelvic floor muscle condition,quality of life,symptom-related score and the level of vaginal cytokines were compared between the two groups,and multivariate Logistic regression model was used to analyze the related factors affecting patients′quality of life.Results After treatment,the total effective rate at the last follow-up of the study group was significantly higher than that of the control group(P<0.05).The scores of UDI-7,PFDI-20 and PFIQ-7 at the last follow-up in the study group were significantly lower than those in the control group(P<0.05).At the last follow-up,TGF-β1 and TIMP-2 in the study group were significantly higher than those in the control group,while MMP-2 was significantly lower than those in the control group(P<0.05).Multivariate Logistic regression analysis showed that the history of 1 delivery was a risk factor leading to no significant improvement in the quality of life of patients after treatment,while therapy assisted with TCM was a protective factor.Conclusions Electric stimulation biofeedback therapy assisted with Buzhong Yiqi Decoction in the treatment of patients with qi-deficiency PFD can effectively improve the pelvic floor function of patients,enhance the efficacy,and improve the quality of life of patients.

关 键 词：盆底功能障碍性疾病 电刺激生物反馈 补中益气汤 生活质量 

分 类 号：R275[医药卫生—中医皮科]