头孢三嗪联合苄青霉素治疗妊娠期梅毒的临床效果及安全性评价  

Clinical efficacy and safety evaluation of ceftriaxone combined with benzylpenicillin in the treatment of syphilis during pregnancy

作　　者：王春侠 杨红 马进 张云涛[2] 邢孝环 WANG Chunxia;YANG Hong;MA Jin;ZHANG Yuntao;XING Xiaohuan(Department of Obstetrics and Gynecology,Tangshan Infectious Diseases Hospital,Tangshan 063001,Hebei,China;Department of Internal Medicine,Tangshan Infectious Diseases Hospital,Tangshan 063001,Hebei,China;Department of Anesthesiology,Tangshan Infectious Diseases Hospital,Tangshan 063001,Hebei,China)

机构地区：[1]唐山市传染病医院妇产科,河北唐山063001 [2]唐山市传染病医院内科,河北唐山063001 [3]唐山市传染病医院麻醉科,河北唐山063001

出　　处：《中国性科学》2021年第2期59-61,共3页Chinese Journal of Human Sexuality

基　　金：河北省卫计委自筹课题项目(20191510)。

摘　　要：目的分析头孢三嗪联合苄青霉素治疗妊娠期梅毒的临床效果及安全性评价。方法选取2016年1月至2017年12月唐山市传染病医院收治的110例妊娠期梅毒患者作为研究对象。根据住院号采取随机原则分为观察组(n=55)和对照组(n=55)。对照组采取苄青霉素治疗,观察组在对照组的基础上联合头孢三嗪治疗。比较两组的临床治疗总有效率、妊娠结局及新生儿预后,同时观察两组的不良反应发生率。结果观察组的临床治疗效果优于对照组,观察组的不良妊娠结局发生率及低体重儿发生率低于对照组,观察组Apgar评分优于对照组,差异具有统计学意义(P<0.05);两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论头孢三嗪联合苄青霉素治疗妊娠期梅毒具有良好的临床治愈率,同时可改善妊娠结局,且安全性较高,可在临床推荐使用。Objective To analyze the clinical efficacy and safety of ceftriaxone combined with benzylpenicillin in the treatment of syphilis during pregnancy.Methods 110 pregnant patients with syphilis admitted to Tangshan Infectious Diseases Hospital from January 2016 to December 2017 were included,and randomly divided into observation group(n=55)and control group(n=55)according to the admission number.The control group was treated with benzypenicillin and the observation group was treated with ceftriaxone combined with benzylpenicillin.The total effective rate,pregnancy outcome and neonatal prognosis of the two groups were compared,and the incidence of adverse reactions between the two groups was observed.Results The clinical treatment efficacy of the observation group was better than that of the control group,the incidence of adverse pregnancy outcomes and the incidence of low birth weight babies in the observation group was lower than that of the control group,and the Apgar score of the observation group was better than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reaction between the two groups(P>0.05).Conclusions ceftriaxone combined with benzylpenicillin in the treatment of syphilis during pregnancy has a good clinical cure rate and high safety,and can improve the outcome of pregnancy,can be recommended in clinical use.

关 键 词：妊娠期梅毒 头孢三嗪 苄青霉素 临床效果 预后 

分 类 号：R714[医药卫生—妇产科学]