卵泡液IGF-1、β-HCG、TGF-β1水平预测体外受精-胚胎移植临床结局的价值  

Follicular fluid IGF-1,β-HCG,TGF-β1 predict the clinical outcome value and influence of in vitro fertili-zation-embryo transfer

作　　者：陈昀 杨小杰[1] 何桦 耿会欣[1] 高丹丽[1] 李桂荣[1] 王婧瑶 林黎明[3] CHEN Yun;YANG Xiaojie;HE Hua;GENG Huixin;GAO Danli;LI Guirong;WANG Jingyao;LIN Liming(Department of Obstetrics and Gynecology,Tangshan Maternal and Child Health Hospital,Tangshan 063000,Hebei,China;Experimental Center,School of Clinical Medicine,North China Uni-versity of Science and Technology,Tangshan 063000,Hebei,China;Department of Cardiology,Kailuan General Hospital,Tangshan 063000,Hebei,China)

机构地区：[1]唐山市妇幼保健院妇产科,河北唐山063000 [2]华北理工大学临床医学院实验中心,河北唐山063000 [3]开滦总医院心内科,河北唐山063000

出　　处：《中国性科学》2021年第3期82-86,共5页Chinese Journal of Human Sexuality

基　　金：2018年度河北省医学科学研究重点课题计划(20181336)。

摘　　要：目的探究卵泡液胰岛素样生长因子-1(IGF-1)、β-人绒毛膜促性腺激素(β-HCG)、转化生长因子-β1(TGF-β1)预测体外受精-胚胎移植(IVF-ET)临床结局价值。方法选取2017年7月至2019年8月唐山市妇幼保健院接受IVF-ET的95例不孕患者作为研究对象。观察IVF-ET结局,分析不同卵泡液IGF-1、β-HCG、TGF-β1水平患者IVF-ET结局的差异,比较妊娠和未妊娠患者卵泡液IGF-1、β-HCG、TGF-β1水平,绘制受试者操作特征(ROC)曲线,分析卵泡液各指标预测IVF-ET结局的价值。结果95例患者中,获卵数、卵裂数、优质胚胎数分别为(17.30±2.28)个、(13.60±2.22)个、(3.94±0.82)个,临床妊娠率为48.42%;高IGF-1、β-HCG水平及低TGF-β1水平患者获卵数、卵裂数、优质胚胎数、临床妊娠率高于低IGF-1、β-HCG水平及高TGF-β1水平患者(P<0.05);妊娠患者卵泡液TGF-β1水平低于未妊娠患者,β-HCG、IGF-1水平高于未妊娠患者(P<0.05);预测IVF-ET结局曲线下面积(AUC):β-HCG<IGF-1<TGF-β1<三者联合。结论卵泡液IGF-1、β-HCG、TGF-β1水平对IVF-ET临床结局均具有良好预测价值,三者联合检测的预测价值最高。Objective To investigate the value of follicular fluid insulin-like growth factor-1(IGF-1),β-human chorionic gonadotropin(β-HCG)and transforming growth factor-β1(TGF-β1)in predicting the clinical out-come of in vitro fertilization and embryo transfer(IVF-ET).Methods 95 infertile patients who received IVF-ET in Tangshan Maternal and Child Health Hospital from July 2017 to August 2019 were selected as the research subjects,to observe the outcome of IVF-ET,and analyze the differences in the outcome of IVF-ET in patients with different levels of IGF-1,β-HCG and TGF-β1 in follicular fluid,and compare the levels of IGF-1,β-HCG and TGF-β1 in follicular fluid in pregnant and non-pregnant patients,and plot receiver operating characteristic(ROC)curve to analyze the val-ue of each index of follicular fluid in predicting the outcome of IVF-ET.Results Among the 95 patients,the number of eggs,cleavage and high-quality embryos were(17.30±2.28),(13.60±2.22)and(3.94±0.82),respectively,and the clinical pregnancy rate was 48.42%.The number of eggs obtained,cleaves,high-quality embryos and the clinical pregnancy rate in patients with high IGF-1,β-hCG and low TGF-β1 levels were higher than those in patients with low IGF-1,β-hCG and high TGF-β1 levels(P<0.05).The levels of TGF-β1 in follicular fluid of pregnant pa-tients were lower than those of non-pregnant patients,and the levels ofβ-HCG and IGF-1 were higher than those of non-pregnant patients(P<0.05).Predicted outcome of IVF-ET AUC:β-HCG<IGF-1<TGF-β1<combination of the three.Conclusions The levels of IGF-1,β-HCG and TGF-β1 in follicular fluid all had good predictive value for the clinical outcome of IVF-ET,and the combined detection of the three had the highest predictive value.

关 键 词：体外受精-胚胎移植 卵泡液 胰岛素样生长因子-1 Β-人绒毛膜促性腺激素 转化生长因子-β1 

分 类 号：R711[医药卫生—妇产科学]